| 000 | 03361nab a2200433 c 4500 | ||
|---|---|---|---|
| 001 | vtls000788285 | ||
| 003 | RU-ToGU | ||
| 005 | 20230131171352.0 | ||
| 007 | cr | | ||
| 008 | 201116|2018 si s a eng dd | ||
| 024 | 7 |
_a10.1142/S1793545818500256 _2doi |
|
| 035 | _ato000788285 | ||
| 040 |
_aRU-ToGU _brus _cRU-ToGU |
||
| 245 | 1 | 0 |
_aOptical in vivo and ex vivo imaging of glioma cells migration via the cerebral vessels: Prospective clinical application of the beta2-adrenoreceptors blockade for glioma treatment _cO. Pavlova, A. Shirokov, A. Fomin [et al.] |
| 336 | _aТекст | ||
| 337 | _aэлектронный | ||
| 504 | _aБиблиогр.: 41 назв. | ||
| 520 | 3 | _aMalignant gliomas are highly invasive tumors that use the cerebral vessels for invasion due to high vascular fragility of the blood–brain barrier (BBB). On one hand, glioma is characterized by the BBB disruption, on the other hand, drug brain delivery via the BBB is a big challenge in glioma therapy. The limited information about vascular changes associated with glioma growth is a reason of slow progress in prevention of glioma development. Here, we present in vivo and ex vivo study of the BBB disruption and glioma cells (GCs) migration in rats using fluorescence and confocal microscopy. We uncovered a local breach in the BBB in the main tumor mass but not within the border of normal and malignant cells, where the BBB was impermeable for high weight molecules. The migration of GCs were observed via the cerebral vessels with the intact BBB that was associated with macrophages infiltration. The mechanisms underlying glioma progression remain unknown but there is an evidence that the sympathetic nervous system (SNS) via activation of vascular beta2-adrenoreceptors (B2-ADRs) can play an important role in tumor metastasis. Our results clearly show an increase in the expression of vascular B2-ADRs and production of the beta-arrestin-1 — co-factor of B2-ADRs signaling pathway in rats with glioma. Pharmacological blockade of B2-ADRs reduces the BBB disruption, macrophages infiltration, GCs migration and increases survival rate. These data suggest that the blockade of B2-ADRs may be a novel adjuvant therapeutic strategy to reduce glioma progression and prevent metastasis. | |
| 653 | _aглиома | ||
| 653 | _aмакрофаги | ||
| 653 | _aгематоэнцефалический барьер | ||
| 653 | _aбета-аррестин | ||
| 655 | 4 |
_aстатьи в журналах _9745982 |
|
| 700 | 1 |
_aShirokov, Alexander _9476778 |
|
| 700 | 1 |
_aFomin, Alexander _9507041 |
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| 700 | 1 |
_aNavolokin, Nikita A. _9113427 |
|
| 700 | 1 |
_aTerskov, Andrey V. _9497292 |
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| 700 | 1 |
_aKhorovodov, Alexander P. _9493742 |
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| 700 | 1 |
_aNamykin, Anton A. _9476775 |
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| 700 | 1 |
_aPavlov, Alexey _9311285 |
|
| 700 | 1 |
_aTuchin, Valery V. _978712 |
|
| 700 | 1 |
_aSemyachkina-Glushkovskaya, Oxana V. _9471534 |
|
| 700 | 1 |
_aPavlova, Olga _9507042 |
|
| 773 | 0 |
_tJournal of innovative optical health sciences _d2018 _gVol. 11, № 4. P. 1850025-1-1850025-10 _x1793-5458 |
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| 852 | 4 | _aRU-ToGU | |
| 856 | 4 | _uhttp://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000788285 | |
| 908 | _aстатья | ||
| 999 | _c474476 | ||