000 03028nab a2200409 c 4500
001 vtls000737052
003 RU-ToGU
005 20230228181308.0
007 cr |
008 201001|2018 xxu s a eng d
024 7 _a10.1117/12.2315213
_2doi
035 _ato000737052
040 _aRU-ToGU
_brus
_cRU-ToGU
245 1 0 _aInvestigation of the change of tumor optical properties after laser-induced plasmon-resonant photothermal treatment of transplanted tumors in rats
_cV. D. Genin, E. A. Genina, A. B. Bucharskaya [et al.]
336 _aТекст
337 _aэлектронный
504 _aБиблиогр.: 17 назв.
520 3 _aThe paper presents the investigation of change of tumor optical properties of the rat tumor doped by gold nanoparticles after laser-induced plasmon-resonant photothermal treatment. To obtain the model tumors the rats have been implanted by suspension of alveolar kidney cancer cells. An hour before the experiment the animals have been injected by the suspension of gold nanorods intratumorally. For irradiation a diode laser with wavelength 808 nm has been used. After the irradiation the tumor has been removed and sliced. Spectra of total and collimated transmission and diffuse reflectance of the samples of different layers of the tumors have been measured in the wavelength range 350-2500 nm. Absorption, scattering, reduced scattering coefficients and scattering anisotropy factor of tumor tissues have been calculated with inverse adding-doubling method. The results of the experiment have shown that after doping the tumor tissue by the plasmon resonant nanoparticles and NIR laser irradiating, there is the decreases of absorption as well as scattering properties of the tumor and surrounding tissues. However, despite the sufficiently high temperature on the surface (about 80°C), the changes in the center of the tumor are insignificant.
653 _aзолотые наностержни
653 _aплазмонно-резонансная фототермическая обработка
653 _aопухоли
653 _aкрысы
653 _aоптические свойства
655 4 _aстатьи в журналах
_9745982
700 1 _aGenina, Elina A.
_9113421
700 1 _aBucharskaya, Alla B.
_9113426
700 1 _aTuchin, Valery V.
_978712
700 1 _aKhlebtsov, Nikolay G.
_9106606
700 1 _aTerentyuk, Georgy S.
_9337941
700 1 _aBashkatov, Alexey N.
_9113422
700 1 _aGenin, Vadim D.
_9504588
773 0 _tProceedings of SPIE
_d2018
_gVol. 10716 : Saratov fall meeting 2017 : Optical technologies in biophysics and medicine XIX, 26-30 September 2017, Saratov, Russian Federation. P. 107160Z-1-107160Z-7
_x0277-786X
852 4 _aRU-ToGU
856 4 _uhttp://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000737052
908 _aстатья
999 _c470604