| 000 | 02918nab a2200445 c 4500 | ||
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| 001 | vtls000673874 | ||
| 003 | RU-ToGU | ||
| 005 | 20210922103426.0 | ||
| 007 | cr | | ||
| 008 | 200121|2018 xxu s a eng d | ||
| 024 | 7 |
_a10.1371/journal.pone.0201829 _2doi |
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| 035 | _ato000673874 | ||
| 040 |
_aRU-ToGU _brus _cRU-ToGU |
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| 245 | 1 | 0 |
_aMicrobiota influence the development of the brain and behaviors in C57BL/6J mice _cJ. Lu, S. Synowiec, L. Lu [et al.] |
| 504 | _aБиблиогр.: 108 назв. | ||
| 520 | 3 | _aWe investigated the contributions of commensal bacteria to brain structural maturation by magnetic resonance imaging and behavioral tests in four and 12 weeks old C57BL/6J specific pathogen free (SPF) and germ free (GF) mice. SPF mice had increased volumes and fractional anisotropy in major gray and white matter areas and higher levels of myelination in total brain, major white and grey matter structures at either four or 12 weeks of age, demonstrating better brain maturation and organization. In open field test, SPF mice had better mobility and were less anxious than GF at four weeks. In Morris water maze, SPF mice demonstrated better spatial and learning memory than GF mice at 12 weeks. In fear conditioning, SPF mice had better contextual memory than GF mice at 12 weeks. In three chamber social test, SPF mice demonstrated better social novelty than GF mice at 12 weeks. Our data demonstrate numerous significant differences in morphological brain organization and behaviors between SPF and GF mice. This suggests that commensal bacteria are necessary for normal morphological development and maturation in the grey and white matter of the brain regions with implications for behavioral outcomes such as locomotion and cognitive functions. | |
| 653 | _aмагнитно-резонансная томография | ||
| 653 | _aмыши | ||
| 653 | _aмикробиота | ||
| 653 | _aсозревание головного мозга | ||
| 653 | _aповеденческие тесты | ||
| 653 | _aкомменсальные бактерии | ||
| 655 | 4 |
_aстатьи в журналах _9745982 |
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| 700 | 1 |
_aSynowiec, Sylvia _9498828 |
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| 700 | 1 |
_aLu, Lei _9498829 |
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| 700 | 1 |
_aYu, Yueyue _9498830 |
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| 700 | 1 |
_aBretherick, Talitha _9498831 |
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| 700 | 1 |
_aTakada, Silvia _9498832 |
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| 700 | 1 |
_aYarnykh, Vasily L. _9102903 |
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| 700 | 1 |
_aCaplan, Jack _9498833 |
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| 700 | 1 |
_aCaplan, Michael _9498834 |
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| 700 | 1 |
_aClaud, Erika C. _9498835 |
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| 700 | 1 |
_aDrobyshevsky, Alexander _9498836 |
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| 700 | 1 |
_aLu, Jing _9498837 |
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| 773 | 0 |
_tPLoS ONE _d2018 _gVol. 13, № 8. P. e0201829 (1-29) _x1932-6203 |
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| 852 | 4 | _aRU-ToGU | |
| 856 | 4 | _uhttp://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000673874 | |
| 908 | _aстатья | ||
| 999 | _c460775 | ||