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008 170213s2015 gw | s |||| 0|eng d
020 _a9783662450741
_9978-3-662-45074-1
024 7 _a10.1007/978-3-662-45074-1
_2doi
035 _ato000561595
040 _aSpringer
_cSpringer
_dRU-ToGU
050 4 _aR895-920
072 7 _aMMPH
_2bicssc
072 7 _aMED019000
_2bisacsh
082 0 4 _a616.0757
_223
245 1 0 _aAutonomic Innervation of the Heart
_helectronic resource
_bRole of Molecular Imaging /
_cedited by Riemer H.J.A. Slart, René A. Tio, Philip H. Elsinga, Markus Schwaiger.
260 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg :
_bImprint: Springer,
_c2015.
300 _aXVII, 465 p. 100 illus., 64 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
505 0 _aIntroduction -- Autonomic nervous system of the heart -- Pathophysiology of the autonomic nervous system of the heart -- Tracers for Presynaptic Cardiac Innervation -- Tracers of Adrenergic Receptors -- Tracers of the Parasympathetic System -- Radiopharmaceuticals production under GMP -- Physics of PET-CT and SPECT-CT -- Kinetics & software PET -- SPECT-CT imaging of autonomic innervation in heart diseases -- PET-CT imaging of autonomic innervation in heart diseases -- Imaging ischemic heart disease -- Imaging diabetes mellitus -- Imaging heart failure -- Imaging amyloidosis -- Imaging heart transplantation -- Imaging ventricular arrhythmias -- Guided therapy & imaging -- Imaging the functional brain-heart axis: neurodegenerative diseases -- Imaging the functional brain-heart axis: mental stress & anxiety -- Imaging cardiotoxicity: the effects of chemo- and mono-clonal antibody therapy on autonomic innervation -- Imaging cardiotoxicity: the effect of radiotherapy on autonomic innervation -- Summary and Future Perspectives: PET-MRI Imaging of cardiac Innervation, fluorescence imaging of cardiac innervation -- Epilog -- Index.
520 _aThis book explains in detail the potential value of the hybrid modalities, SPECT-CT and PET-CT, in the imaging of cardiac innervation in a wide range of conditions and diseases, including ischemic heart disease, diabetes mellitus, heart failure, amyloidosis, heart transplantation, and ventricular arrhythmias. Imaging of the brain-heart axis in neurodegenerative disease and stress and of cardiotoxicity is also discussed. The roles of the various available tracers are fully considered, and individual chapters address radiopharmaceutical development under GMP, imaging physics, and kinetic modeling software. Highly relevant background information is included on the autonomic nervous system of the heart and its pathophysiology, and in addition future perspectives are discussed. Awareness of the importance of autonomic innervation of the heart for the optimal management of cardiac patients is growing, and there is an evident need for objective measurement techniques or imaging modalities. In this context, Autonomic Innervation of the Heart will be of wide interest to clinicians, researchers, and industry.
650 0 _amedicine.
_9566220
650 0 _aRadiology.
_9281356
650 0 _aNuclear medicine.
_9566268
650 0 _aCardiology.
_9302215
650 1 4 _aMedicine & Public Health.
_9566221
650 2 4 _aDiagnostic Radiology.
_9303671
650 2 4 _aNuclear Medicine.
_9566269
650 2 4 _aCardiology.
_9302215
700 1 _aSlart, Riemer H.J.A.
_eeditor.
_9470422
700 1 _aTio, René A.
_eeditor.
_9470423
700 1 _aElsinga, Philip H.
_eeditor.
_9470424
700 1 _aSchwaiger, Markus.
_eeditor.
_9327847
710 2 _aSpringerLink (Online service)
_9143950
773 0 _tSpringer eBooks
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-662-45074-1
912 _aZDB-2-SME
999 _c417046