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008 170213s2015 gw | s |||| 0|eng d
020 _a9783662440063
_9978-3-662-44006-3
024 7 _a10.1007/978-3-662-44006-3
_2doi
035 _ato000561473
040 _aSpringer
_cSpringer
_dRU-ToGU
050 4 _aRC1-1245
072 7 _aMJ
_2bicssc
072 7 _aMED045000
_2bisacsh
082 0 4 _a616
_223
245 1 0 _aCancer Immunology
_helectronic resource
_bA Translational Medicine Context /
_cedited by Nima Rezaei.
260 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg :
_bImprint: Springer,
_c2015.
300 _aXLVII, 597 p. 269 illus., 246 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
505 0 _aIntroduction on cancer immunology and immunotherapy -- Inflammatory and innate immune cells in cancer microenvironment and progression -- Role of innate immunity in cancers and antitumor response -- Role of B cells in anti tumor response -- The role of exhaustion in tumor-induced T cell dysfunction in patients with cancer -- Regulatory T cells and Th17 cells in the immunosuppressive tumor network -- Role of cytokines in tumor immunity and immune tolerance to cancers -- Role of chemokines and chemokine receptors in cancers -- The role of Fas and Fas-ligand in cancers -- MHC class I molecules and cancer progression: Lessons learned from preclinical tumor models -- Role of plasmacytoid dendritic cells in cancer -- Cancer immunoediting: immunosurveillance, immuneequilibrium, and immune escape -- Apoptosis, autophagy and necroptosis in Cancer -- Prognostic value of innate and adaptive immunity in cancers -- Epigenetics and Micro RNAs in cancers -- Immunogenetics of cancers -- Immunodeficiencies and cancers -- Immunosenescence and cancers -- Nutrition, immunity and cancers -- Allergies and cancers -- Cancer immunology of transmissible cancers -- Systems biology and systems immunology of cancer -- Principles of immunological diagnostic tests for cancers -- Flow cytometry in cancer immunotherapy: applications, analysis, quality control and future -- Immunohistochemistry of cancers -- Immunology and immunotherapy of graft versus host disease.   .
520 _aCancer Immunology is intended as an up-to-date, clinically relevant review of cancer immunology and immunotherapy. The rapid flow of studies in the field of cancer immunology during the last decade has increased our understanding of the interactions between the immune system and cancerous cells. In particular, it is now well known that such interactions result in the induction of epigenetic changes in cancerous cells and the selection of less immunogenic clones as well as alterations in immune responses. Understanding the cross-talk between nascent transformed cells and cells of the immune system has led to the development of combinatorial immunotherapeutic strategies to combat cancer. This volume is focused on interactions between cancerous cells and various components of the innate and adaptive immune system are fully described. Notably, the principal focus is very much on clinical aspects, the aim being to educate clinicians on the clinical implications of the most recent findings and novel developments in the field. This is to be hoped that this translational book will be comprehensible, cogent and of special value for researchers and clinicians who wish to extend their knowledge on cancer immunology.   .
650 0 _amedicine.
_9566220
650 0 _aImmunology.
_9303380
650 0 _aInternal medicine.
_9566286
650 0 _aHematology.
_9307898
650 0 _aOncology.
_9303086
650 1 4 _aMedicine & Public Health.
_9566221
650 2 4 _aInternal Medicine.
_9566287
650 2 4 _aImmunology.
_9303380
650 2 4 _aOncology.
_9303086
650 2 4 _aHematology.
_9307898
700 1 _aRezaei, Nima.
_eeditor.
_9330147
710 2 _aSpringerLink (Online service)
_9143950
773 0 _tSpringer eBooks
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-662-44006-3
912 _aZDB-2-SME
999 _c416193