000 03248nam a22004935i 4500
001 vtls000561184
003 RU-ToGU
005 20210922090501.0
007 cr nn 008mamaa
008 170213s2015 gw | s |||| 0|eng d
020 _a9783642312205
_9978-3-642-31220-5
024 7 _a10.1007/978-3-642-31220-5
_2doi
035 _ato000561184
040 _aSpringer
_cSpringer
_dRU-ToGU
050 4 _aRM845-862.5
072 7 _aMJCL1
_2bicssc
072 7 _aMED080000
_2bisacsh
082 0 4 _a615.842
_223
245 1 0 _aBreast Cancer Biology for the Radiation Oncologist
_helectronic resource
_cedited by Jonathan Strauss, William Small, Gayle E. Woloschak.
260 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg :
_bImprint: Springer,
_c2015.
300 _aVII, 90 p. 15 illus., 5 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
490 1 _aMedical Radiology,
_x0942-5373
505 0 _aBiological subtypes of breast cancer -- Oncogene amplification and Herceptin -- Current clinical use of genetic profiling -- Biology of DCIS and progression to invasive disease -- Cancer Stem Cells and Radiotherapy -- Genetic basis of normal tissue radiosensitivity and late toxicity -- Genetic syndromes and radiotherapy in breast cancer -- Experimental therapies in breast cancer.
520 _aBreast Cancer Biology for the Radiation Oncologist is the first textbook of its kind devoted to describing the biological complexities of breast cancer in a way that is relevant to the radiation oncologist. Radiation Oncology has long treated breast cancer as a single biological entity, with all treatment decisions being based on clinical and pathologic risk factors. We are now beginning to understand that biological subtypes of breast cancer may have different risks of recurrence as well as different intrinsic sensitivity to radiotherapy. Multi-gene arrays that have for years been used to predict the risk of distant recurrence and the value of systemic chemotherapy may also have utility in predicting the risk of local recurrence. Additionally, the targeted agents used to treat breast cancer may interact with radiotherapy in ways that can be beneficial or undesirable. All of these emerging issues of central importance to radiation oncologists are extensively discussed in this book, and practical treatment recommendations based on available clinical evidence are presented whenever possible.
650 0 _amedicine.
_9566220
650 0 _aRadiotherapy.
_9307053
650 0 _aOncology.
_9303086
650 1 4 _aMedicine & Public Health.
_9566221
650 2 4 _aRadiotherapy.
_9307053
650 2 4 _aOncology.
_9303086
700 1 _aStrauss, Jonathan.
_eeditor.
_9468826
700 1 _aSmall, William.
_eeditor.
_9318705
700 1 _aWoloschak, Gayle E.
_eeditor.
_9318706
710 2 _aSpringerLink (Online service)
_9143950
773 0 _tSpringer eBooks
830 0 _aMedical Radiology,
_9324828
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-31220-5
912 _aZDB-2-SME
999 _c416059