000 03578nam a22004575i 4500
001 vtls000561452
003 RU-ToGU
005 20210922090425.0
007 cr nn 008mamaa
008 170213s2015 gw | s |||| 0|eng d
020 _a9783662437339
_9978-3-662-43733-9
024 7 _a10.1007/978-3-662-43733-9
_2doi
035 _ato000561452
040 _aSpringer
_cSpringer
_dRU-ToGU
050 4 _aRK529-535
072 7 _aMMDS
_2bicssc
072 7 _aMED085020
_2bisacsh
082 0 4 _a617.522059
_223
245 1 0 _aMedication-Related Osteonecrosis of the Jaws
_helectronic resource
_bBisphosphonates, Denosumab, and New Agents /
_cedited by Sven Otto.
260 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg :
_bImprint: Springer,
_c2015.
300 _aVIII, 220 p. 83 illus., 63 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
505 0 _aPharmacology of Antiresorptive Drugs -- The Role of Antiresorptive Drugs in the Treatment of Osteoporosis -- The Role of Antiresorptive Drugs in the Treatment of Skeletal Manifestations of Malignant Diseases -- Clinical Features, Localization, Definition and Staging of the Disease -- Radiological Findings / Imaging -- General Characteristics and Risk Factors for BRONJ -- Epidemiology -- Histopathology of BRONJ -- Prevention of Osteonecrosis and Dentoalveolar Surgery Under Treatment With Antiresorptive Drugs -- Bisphosphonates and Dental Implants -- Treatment of BRONJ -- Local and Microvascular Flaps in ONJ-Treatment -- Rehabilitation of Patients After BRONJ -- Adjuvant Treatment Strategies -- Microbiology and Antibiotics -- Animal Models of ONJ -- ONJ Under Denosumab and Other New Drugs -- Possible Use of Antiresorptive Drugs in OMS -- Dental Treatment Under BPs and After BRONJ -- Dental Rehabilitation Under Bisphosphonates and After BRONJ -- History of ONJ.
520 _aOsteonecrosis of the jaws is a well-known side-effect of antiresorptive therapy that predominantly occurs in patients suffering from malignant diseases and receiving intravenous administrations of nitrogen-containing bisphosphonates or subcutaneous administrations of denosumab, a monoclonal antibody. Less frequently it may also be observed in patients with osteoporosis who are being treated with these antiresorptive drugs.  This textbook provides detailed, up-to-date information on all aspects of medication-related osteonecrosis of the jaws, including clinical features, pathogenesis, treatment options, and preventive measures. It also explains safe prevention and treatment strategies for patients receiving antiresorptive drugs who require extractions, implant insertions, and other dento-alveolar surgeries. This book will be of major interest for medical and dental students, dentists, and oral and maxillofacial surgeons as well as osteologists and oncologists.
650 0 _aDentistry.
_9310059
650 0 _amedicine.
_9566220
650 0 _aOral surgery.
_9460884
650 0 _aMaxillofacial surgery.
_9460885
650 1 4 _aMedicine & Public Health.
_9566221
650 2 4 _aOral and Maxillofacial Surgery.
_9315636
650 2 4 _aDentistry.
_9310059
700 1 _aOtto, Sven.
_eeditor.
_9468527
710 2 _aSpringerLink (Online service)
_9143950
773 0 _tSpringer eBooks
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-662-43733-9
912 _aZDB-2-SME
999 _c415856