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020 _a9783319211008
_9978-3-319-21100-8
024 7 _a10.1007/978-3-319-21100-8
_2doi
035 _ato000560421
040 _aSpringer
_cSpringer
_dRU-ToGU
050 4 _aQR355-502
072 7 _aMMFM
_2bicssc
072 7 _aMED052000
_2bisacsh
082 0 4 _a616.9101
_223
245 1 0 _aHuman Papillomavirus (HPV)-Associated Oropharyngeal Cancer
_helectronic resource
_cedited by Daniel L. Miller, M. Sharon Stack.
250 _a1st ed. 2015.
260 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2015.
300 _aVIII, 314 p. 29 illus., 22 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
505 0 _aEpidemiology of HPV-Associated Oropharyngeal Squamous Cell Carcinoma -- Behavioral Correlates of HPV-Associated Oropharyngeal Squamous Cell Carcinomas -- Racial Disparities in Oropharyngeal Cancer -- HPV Virology: Cellular Targets of HPV Oncogenes and Transformation -- Papillomavirus Replication -- MicroRNA Profiles of HPV-Associated  Oropharyngeal Squamous Cell Carcinoma (OPSCC) -- Targeting the PI3K-mTOR Signaling Circuitry in HPV-Associated Oral Malignancies: Novel Precision Molecular Therapies -- Mutational Profile of HPV-Positive HNSCC -- Clinical Presentation of HPV-driven Oropharyngeal Carcinoma -- Differences and Similarities between HPV-Associated OPSCC and Cervical Cancer -- Surgical Perspective in the Management of Oropharyngeal Cancer -- HPV and Radiation Sensitivity -- The Role of Immune Modulation in the Carcinogenesis and Treatment of HPV-associated Oropharyngeal Cancer.
520 _aHead and neck squamous cell carcinoma (HNSCC), the sixth most prevalent cancer worldwide, remains a very difficult disease to treat and cure despite intensive investigation into molecular etiologies and tumor progression pathways. Due to public health efforts encouraging smoking cessation, the overall incidence of HNSCC has decreased in recent years in many countries.  In contrast, the incidence of oropharyngeal squamous cell carcinoma (OPSCC) has increased significantly, and this subtype of HNSCC is commonly associated with human papillomavirus (HPV) infection.  Moreover, individuals with HPV-positive OPSCC are generally younger and are frequently non-smokers, suggesting that HPV-associated OPSCC represents a distinct biologic entity.   This volume summarizes the spectrum of current HPV-associated OPSCC research from the fundamental basic science to translational surgery and treatment approaches. Chapters are contributed by authoritative leaders in the fields of research and clinical care. Initial chapters address epidemiology, behavioral correlates of HPV infection, and racial disparities in oropharyngeal cancer. This is followed by chapters detailing HPV virology with focus on viral transformation, viral replication, and host response to viral infection. The molecular biology of HPV-associated OPSCC is investigated in chapters detailing alterations in signaling networks and unique mutational profiles of human tumors. Clinical presentation, surgical perspectives, and treatment paradigms specific to HPV-associated OPSCC conclude the volume.  This comprehensive volume provides an up-to-date overview of both scientific discovery and clinical management of this emerging public health problem.
650 0 _amedicine.
_9566220
650 0 _aCancer Research.
_9566267
650 0 _aImmunology.
_9303380
650 0 _aMedical Microbiology.
_9303382
650 0 _aVirology.
_9303545
650 1 4 _aBiomedicine.
_9566246
650 2 4 _aVirology.
_9303545
650 2 4 _aCancer Research.
_9566267
650 2 4 _aImmunology.
_9303380
650 2 4 _aMedical Microbiology.
_9303382
700 1 _aMiller, Daniel L.
_eeditor.
_9468300
700 1 _aStack, M. Sharon.
_eeditor.
_9468301
710 2 _aSpringerLink (Online service)
_9143950
773 0 _tSpringer eBooks
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-319-21100-8
912 _aZDB-2-SBL
999 _c415714