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008 | 170212s2015 gw | s |||| 0|eng d | ||
020 |
_a9783319205441 _9978-3-319-20544-1 |
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024 | 7 |
_a10.1007/978-3-319-20544-1 _2doi |
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040 |
_aSpringer _cSpringer _dRU-ToGU |
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_aSCI013040 _2bisacsh |
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_a547 _223 |
100 | 1 |
_aDoran, Robert. _eauthor. _9467833 |
|
245 | 1 | 0 |
_aAsymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of α-Aryl Ketones _helectronic resource _cby Robert Doran. |
260 |
_aCham : _bSpringer International Publishing : _bImprint: Springer, _c2015. |
||
300 |
_aXXI, 202 p. 258 illus., 3 illus. in color. _bonline resource. |
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336 |
_atext _btxt _2rdacontent |
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337 |
_acomputer _bc _2rdamedia |
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338 |
_aonline resource _bcr _2rdacarrier |
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490 | 1 |
_aSpringer Theses, Recognizing Outstanding Ph.D. Research, _x2190-5053 |
|
505 | 0 | _aIntroduction to the Total Synthesis of Lactone-Containing Natural Products using ZrCl4 -- Asymmetric Synthesis of the β-Methyl-Substituted Analogues of (+)-Tanikolide and (–)-Malyngolide -- Asymmetric Synthesis of Both Enantiomers of a d-Lactone Analogue of Muricatacin -- Introduction to the Development of a Catalytic Asymmetric Synthesis of Tertiary α-Aryl Ketones -- A Stereoselective Switch: Enantiodivergent Approach to the Synthesis of Isoflavanones -- Asymmetric Synthesis of Tertiary α-Aryl Ketones by Decarboxylative Asymmetric Protonation. | |
520 | _aThis thesis addresses two fundamental areas in contemporary organic chemistry: synthesis of natural products and catalytic asymmetric synthesis. Firstly, a new methodology, developed by our research group, which allows the asymmetric synthesis of lactones, a structural unit ubiquitous in natural products, was utilised in the synthesis of a number of natural product analogues that showed significant biological activity. Secondly, the development of a catalytic asymmetric synthesis of a key structural motif present in a number of natural products and pharmaceuticals was accomplished. During the course of this work we discovered dual stereocontrol, which is significant because it allows the configuration of a new stereocentre to be controlled by a simple change of proton source. | ||
650 | 0 |
_achemistry. _9161768 |
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650 | 0 |
_aOrganic Chemistry. _9299061 |
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650 | 0 |
_aMedicinal Chemistry. _9305147 |
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650 | 0 |
_aCatalysis. _9308199 |
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650 | 1 | 4 |
_aChemistry. _9161768 |
650 | 2 | 4 |
_aOrganic Chemistry. _9299061 |
650 | 2 | 4 |
_aCatalysis. _9308199 |
650 | 2 | 4 |
_aMedicinal Chemistry. _9305147 |
710 | 2 |
_aSpringerLink (Online service) _9143950 |
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773 | 0 | _tSpringer eBooks | |
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_aSpringer Theses, Recognizing Outstanding Ph.D. Research, _9567110 |
|
856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-3-319-20544-1 |
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999 | _c415421 |