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008 170212s2015 gw | s |||| 0|eng d
020 _a9783319246635
_9978-3-319-24663-5
024 7 _a10.1007/978-3-319-24663-5
_2doi
035 _ato000560876
040 _aSpringer
_cSpringer
_dRU-ToGU
050 4 _aR-RZ
072 7 _aMBGR
_2bicssc
072 7 _aMED000000
_2bisacsh
082 0 4 _a610
_223
100 1 _aRibatti, Domenico.
_eauthor.
_9316431
245 1 4 _aThe Development of Immunologic Competence
_helectronic resource
_cby Domenico Ribatti.
250 _a1st ed. 2015.
260 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2015.
300 _aVIII, 60 p. 29 illus., 7 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
505 0 _aPreface.- Introduction.- Human hematopoietic development.-The Bursa of Fabricius.- The Thymus.- Clinical correlates -- References -- Index.                      .
520 _aThis book traces significant aspects of the history of immunology, exploring the immune system and immunodeficiency. The author recounts human hematopoietic development, and how a distinction of the immune system into thymus-dependent and thymus-independent components has been demonstrated in different animal species, including amphibians, birds, and mammals. Other themes explored in this book include discoveries about the role of the thymus of the Bursa of Fabricius in the development of immunologic competence, and observations on the changes in the lymphoid organs after bursectomy and thymectomy in chickens. Readers will discover how the bursa provides a unique microenvironment for the proliferation and differentiation of B cells, while thymectomized and irradiated animals were deficient in lymphocytes that mediated inflammatory responses, as assessed by skin graft rejection, delayed-type hypersensitivity, and graft versus host reaction. A clear perspective for understanding several diseases and also the entire lymphoid system emerges through the experiments and extensive histopathological studies of patients with primary immunodeficiency diseases that are described in these chapters. Researchers in the life sciences, in biomedicine and the history of medicine will all find something of value in this highly engaging work. It will also appeal to those with an interest in public health and neurobiology.
650 0 _amedicine.
_9566220
650 0 _aLife Sciences.
_9295653
650 1 4 _aBiomedicine.
_9566246
650 2 4 _aBiomedicine general.
_9566281
650 2 4 _aMedicine/Public Health, general.
_9265983
650 2 4 _aLife Sciences, general.
_9303679
710 2 _aSpringerLink (Online service)
_9143950
773 0 _tSpringer eBooks
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-319-24663-5
912 _aZDB-2-SBL
999 _c415370