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008 | 170212s2015 gw | s |||| 0|eng d | ||
020 |
_a9783319246635 _9978-3-319-24663-5 |
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024 | 7 |
_a10.1007/978-3-319-24663-5 _2doi |
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035 | _ato000560876 | ||
040 |
_aSpringer _cSpringer _dRU-ToGU |
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_aMBGR _2bicssc |
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_aMED000000 _2bisacsh |
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_a610 _223 |
100 | 1 |
_aRibatti, Domenico. _eauthor. _9316431 |
|
245 | 1 | 4 |
_aThe Development of Immunologic Competence _helectronic resource _cby Domenico Ribatti. |
250 | _a1st ed. 2015. | ||
260 |
_aCham : _bSpringer International Publishing : _bImprint: Springer, _c2015. |
||
300 |
_aVIII, 60 p. 29 illus., 7 illus. in color. _bonline resource. |
||
336 |
_atext _btxt _2rdacontent |
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337 |
_acomputer _bc _2rdamedia |
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338 |
_aonline resource _bcr _2rdacarrier |
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505 | 0 | _aPreface.- Introduction.- Human hematopoietic development.-The Bursa of Fabricius.- The Thymus.- Clinical correlates -- References -- Index. . | |
520 | _aThis book traces significant aspects of the history of immunology, exploring the immune system and immunodeficiency. The author recounts human hematopoietic development, and how a distinction of the immune system into thymus-dependent and thymus-independent components has been demonstrated in different animal species, including amphibians, birds, and mammals. Other themes explored in this book include discoveries about the role of the thymus of the Bursa of Fabricius in the development of immunologic competence, and observations on the changes in the lymphoid organs after bursectomy and thymectomy in chickens. Readers will discover how the bursa provides a unique microenvironment for the proliferation and differentiation of B cells, while thymectomized and irradiated animals were deficient in lymphocytes that mediated inflammatory responses, as assessed by skin graft rejection, delayed-type hypersensitivity, and graft versus host reaction. A clear perspective for understanding several diseases and also the entire lymphoid system emerges through the experiments and extensive histopathological studies of patients with primary immunodeficiency diseases that are described in these chapters. Researchers in the life sciences, in biomedicine and the history of medicine will all find something of value in this highly engaging work. It will also appeal to those with an interest in public health and neurobiology. | ||
650 | 0 |
_amedicine. _9566220 |
|
650 | 0 |
_aLife Sciences. _9295653 |
|
650 | 1 | 4 |
_aBiomedicine. _9566246 |
650 | 2 | 4 |
_aBiomedicine general. _9566281 |
650 | 2 | 4 |
_aMedicine/Public Health, general. _9265983 |
650 | 2 | 4 |
_aLife Sciences, general. _9303679 |
710 | 2 |
_aSpringerLink (Online service) _9143950 |
|
773 | 0 | _tSpringer eBooks | |
856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-3-319-24663-5 |
912 | _aZDB-2-SBL | ||
999 | _c415370 |