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020 _a9783319192949
_9978-3-319-19294-9
024 7 _a10.1007/978-3-319-19294-9
_2doi
035 _ato000560053
040 _aSpringer
_cSpringer
_dRU-ToGU
050 4 _aRB1-214
072 7 _aMMF
_2bicssc
072 7 _aMED067000
_2bisacsh
082 0 4 _a616.07
_223
245 1 0 _aAmyloid and Related Disorders
_helectronic resource
_bSurgical Pathology and Clinical Correlations /
_cedited by Maria M. Picken, Guillermo A. Herrera, Ahmet Dogan.
260 _aCham :
_bSpringer International Publishing :
_bImprint: Humana Press,
_c2015.
300 _aXIX, 542 p. 391 illus., 345 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
490 1 _aCurrent Clinical Pathology,
_x2197-781X
505 0 _aIntroduction/general -- Aspects of the history and nomenclature of amyloid and amyloidosis -- Amyloid diseases at the molecular level: general overview and focus on AL amyloidosis -- AA amyloidosis -- Non-Immunoglobulin and non-AA amyloidoses -- The hereditary amyloidoses -- Dialysis-associated amyloidosis -- Localized amyloidoses and amyloidoses associated with aging outside the central nervous system -- Central nervous system amyloid -- Non-amyloid protein deposits -- Differential diagnosis of amyloid in surgical pathology: organized deposits and other material in the differential diagnosis of amyloidosis -- Light /heavy chain deposition disease as a systemic disease -- Glomerulonephritis with non-organized monoclonal immunoglobulin deposits -- Pathologies of renal and systemic intracellular paraprotein storage: crystalopathies and beyond -- Diagnosis -- Diagnosis of amyloid using Congo red – polarized and fluorescence -- Thioflavin T stain for amyloid detection -- Fat tissue analysis in the management of patients with systemic amyloidosis -- Generic diagnosis of amyloid – recent developments and summary of current recommendations -- Amyloid typing on formalin-fixed paraffin sections by immunohistochemistry – experience from two large referral centers -- Options for amyloid typing in renal pathology – the advantages of frozen section immunofluorescence -- Amyloid typing by immuno-electron microscopy -- Classification of amyloidosis by mass spectrometry-based proteomics -- Summary and practical recommendation regarding amyloid typing using antibody-based and proteomic methods -- Ancillary studies of amyloidosis -- Laboratory support for diagnosis of amyloidosis -- Bone marrow biopsy and its utility in the diagnosis of AL amyloidosis and other plasma cell dyscrasias -- Molecular methods for the diagnosis of hereditary amyloidosis -- Radiologic support for diagnosis and monitoring of amyloidosis – established techniques and recent developments -- Organ involvement in amyloidoses -- Amyloidoses of the Kidney and Genitourinary tract -- Cardiac amyloidosis -- Amyloidosis of the Gastrointestinal tract and Liver -- Peripheral nerve amyloidosis -- Amyloidoses of the Pulmonary and upper respiratory tract -- Amyloidoses involving the skin -- Clinical issues and therapy -- Clinico-pathologic issues in patients with amyloidosis -- Solid organ transplantation in amyloidosis and issues pertaining to domino liver transplantation -- Emerging therapies for amyloidosis -- Clinical trials -- Modern therapies in AA amyloidosis -- Medico legal issues of amyloidosis -- Amyloidosis from the patient’s perspective.
520 _aThe second edition of this text presents an overview of the most recent developments in this area including clinical presentation, etiology, pathogenesis, and differential diagnosis. The rationale for various therapies, including transplantation, is discussed and tissue diagnosis (its pitfalls and strategies for avoiding them) and laboratory support are included. The involvement of all major organ systems including renal/genitourinary, cardiac, gastrointestinal, pulmonary, peripheral nerve/central nervous system, soft tissue, skin, lymph node/spleen and bone marrow pathology is also covered. Amyloid and Related Disorders, Second Edition will be invaluable to specialized and general pathologists as well as cytopathologists. Other medical professionals may also benefit from this concise update on the systemic amyloidoses.
650 0 _amedicine.
_9566220
650 0 _aNephrology.
_9303646
650 0 _aOncology.
_9303086
650 0 _aPathology.
_9303087
650 1 4 _aMedicine & Public Health.
_9566221
650 2 4 _aPathology.
_9303087
650 2 4 _aNephrology.
_9303646
650 2 4 _aOncology.
_9303086
700 1 _aPicken, Maria M.
_eeditor.
_9466822
700 1 _aHerrera, Guillermo A.
_eeditor.
_9466823
700 1 _aDogan, Ahmet.
_eeditor.
_9466824
710 2 _aSpringerLink (Online service)
_9143950
773 0 _tSpringer eBooks
830 0 _aCurrent Clinical Pathology,
_9316600
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-319-19294-9
912 _aZDB-2-SME
999 _c414784