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008 170212s2015 gw | s |||| 0|eng d
020 _a9783319187532
_9978-3-319-18753-2
024 7 _a10.1007/978-3-319-18753-2
_2doi
035 _ato000559909
040 _aSpringer
_cSpringer
_dRU-ToGU
050 4 _aRS400-431
072 7 _aPSB
_2bicssc
072 7 _aSCI013020
_2bisacsh
082 0 4 _a615.19
_223
100 1 _aHatton, Fiona L.
_eauthor.
_9466430
245 1 0 _aHyperbranched Polydendrons
_helectronic resource
_bA New Macromolecular Architecture /
_cby Fiona L. Hatton.
260 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2015.
300 _aXXII, 260 p. 218 illus., 9 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
490 1 _aSpringer Theses, Recognizing Outstanding Ph.D. Research,
_x2190-5053
505 0 _aIntroduction -- Synthesis and characterisation of hyp-polydendron materials and subsequent anoparticle formation -- Mixing dendron and PEG initiators for the polymerisation of branched pHPMA and aqueous nanoparticle formation -- Mixing dendron and PEG initiators for the polymerisation of branched pHPMA and formation of sterically stabilised nanoparticles -- Hyp-Polydendrons; studies of nanoprecipitation behavior -- Conclusions and Future work -- Experimental.
520 _aThis thesis outlines the first synthesis of a new complex branched polymer architecture that aims to combine the benefits of dendrimers with the simplicity of conventional polymerisation. There is no other available literature on these remarkable materials, dubbed hyperbranched polydendrons, due to their novelty. The new materials were shown to have very high molecular weights (>1,000,000 g/mol), exceptional self-assembly and encapsulation behaviour and unparalleled functionalisation capabilities, and were studied pharmacologically to determine their potential as oral nanomedicine candidates. The detailed investigation of the chemical variables involved in synthesising hyperbranched polydendrons has shown that their self-assembly and pharmacological behaviour can be turned on and off and fine-tuned by altering the composition of the materials. The permeation of the self-assembled particles through model gut epithelium suggests the potential for oral dosing of drug loaded nanomedicines that result in circulating nanoparticles – a research goal that is currently being pursued by several groups around the globe.
650 0 _achemistry.
_9161768
650 0 _aPolymers.
_9303538
650 0 _aMedicinal Chemistry.
_9305147
650 0 _aNanochemistry.
_9410477
650 1 4 _aChemistry.
_9161768
650 2 4 _aMedicinal Chemistry.
_9305147
650 2 4 _aPolymer Sciences.
_9303539
650 2 4 _aNanochemistry.
_9410477
710 2 _aSpringerLink (Online service)
_9143950
773 0 _tSpringer eBooks
830 0 _aSpringer Theses, Recognizing Outstanding Ph.D. Research,
_9567110
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-319-18753-2
912 _aZDB-2-CMS
999 _c414539