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020 _a9783319188812
_9978-3-319-18881-2
024 7 _a10.1007/978-3-319-18881-2
_2doi
035 _ato000559941
040 _aSpringer
_cSpringer
_dRU-ToGU
050 4 _aQH491
072 7 _aPSF
_2bicssc
072 7 _aSCI072000
_2bisacsh
082 0 4 _a571.86
_223
245 1 4 _aThe Male Role in Pregnancy Loss and Embryo Implantation Failure
_helectronic resource
_cedited by Richard Bronson.
260 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2015.
300 _aX, 228 p. 20 illus., 12 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
490 1 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v868
505 0 _aPreface -- Meiotic Non-disjunction - Insights into the Origin and Significance of Aneuploidy in Human Spermatozoa -- Damage to Sperm DNA Mediated by Reactive Oxygen Species: Its Impact on Human Reproduction and the Health Trajectory of Offspring -- Small RNAs: Their Possible Roles in Reproductive Failure -- The Sperm Epigenome, Male Aging and Potential Effects on the Embryo -- The Role of Uterine NK Cells in Normal Reproduction and Reproductive Disorders -- Seminal fluid Signaling in the Female Reproductive Tract: Implications for Reproductive Success and Offspring Health -- Role of Seminal Plasma in Human Female Reproductive Failure:  Immunomodulation, Inflammation and Infections -- Human Leukocyte Antigen-G Within the Male Reproductive System - Implications for Reproduction -- Prostasomes - Their Characterization: Implications for Human Reproduction -- The Paternal Contribution to Fetal Tolerance -- Index.
520 _aNovel topics compiled in this one-of-a-kind volume provide tantalizing hints for clinical application through future translational research. Only recently have we come to ask what role the male might play in pregnancy loss and embryo implantation failure, beyond contributing an abnormal set of paternal chromosomes at fertilization. This volume explores the recent evidence that these conditions might also be related to the transmission of previously unrecognized chromosomal micro-deletions and duplications, or via the epigenetic dysregulation of early embryonic gene function by spermatozoal microRNAs or alterations in sperm DNA methylation patterning, or by DNA damage secondary to either reactive oxygen species or environmental toxicants. In addition, the composition of seminal plasma has been found to be highly complex, containing many factors that play important roles in altering the uterine environment and the female immune system permissive of embryo implantation and trophectoderm outgrowth leading to successful pregnancy. Coverage includes an examination of both spermatozoa and seminal fluid component factors.
650 0 _aLife Sciences.
_9295653
650 0 _aCytogenetics.
_9413495
650 0 _aReproductive Medicine.
_9302989
650 0 _aEmbryology.
_9413371
650 1 4 _aLife Sciences.
_9295653
650 2 4 _aEmbryology.
_9413371
650 2 4 _aReproductive Medicine.
_9302989
650 2 4 _aCytogenetics.
_9413495
700 1 _aBronson, Richard.
_eeditor.
_9127718
710 2 _aSpringerLink (Online service)
_9143950
773 0 _tSpringer eBooks
830 0 _aAdvances in Experimental Medicine and Biology,
_9303385
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-319-18881-2
912 _aZDB-2-SBL
999 _c414320