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008 170212s2015 gw | s |||| 0|eng d
020 _a9783319155180
_9978-3-319-15518-0
024 7 _a10.1007/978-3-319-15518-0
_2doi
035 _ato000559011
040 _aSpringer
_cSpringer
_dRU-ToGU
050 4 _aRM1-950
072 7 _aMMG
_2bicssc
072 7 _aMED071000
_2bisacsh
082 0 4 _a615
_223
245 1 0 _aToxicological Effects of Perfluoroalkyl and Polyfluoroalkyl Substances
_helectronic resource
_cedited by Jamie C. DeWitt.
260 _aCham :
_bSpringer International Publishing :
_bImprint: Humana Press,
_c2015.
300 _aXIII, 495 p. 49 illus., 15 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
490 1 _aMolecular and Integrative Toxicology,
_x2168-4219
505 0 _aPerfluorinated compounds: An overview -- Analysis of PFASs in biological tissues and fluids -- PFASs in the general population -- PFAS Biomonitoring in Higher Exposed Populations -- Perfluorinated Alkyl Acids in Wildlife -- Metabolism and Pharmacokinetics -- Metabolic EffectsPFAS -- Developmental Toxicity -- Neurotoxicity -- Immunotoxicity of Perfluoroalkylated Compounds -- Effects of PFOA on Endocrine-related Systems -- Carcinogenicity of Perfluoroalkyl Compounds -- Epidemiological Findings -- Dosimetric Anchoring of Toxicological Studies -- Human Health Risk Assessment of Perfluoroalkyl Acids -- Systematic Review, An Illustration of Increased Transparency in a Framework for Evaluating Immunotoxicity Associated with PFOA and PFOS Exposure -- Toxicology data for alternative “short-chain” fluorinated substances -- Conclusions and recommendations.  .
520 _aThis book serves as a timely and comprehensive overview of the latest science for perfluoroalkyl and polyfluoroalkyl substances (PFASs), covering the development of methods for assessing PFASs in biological fluids and tissues as well as the current knowledge regarding their toxicity to vertebrate organisms. This book includes chapters on human and wildlife exposure/body burdens, reviews of metabolism and toxicological effects by organ system/developmental stage, and aspects of PFAS toxicity that are driving PFAS research and regulatory oversight. Toxicological Effects of Perfluoroalkyl and Polyfluoroalkyl Substances provides critical assessments of the most controversial topics surrounding toxicological evaluation of PFASs to give readers an expert perspective on the issues. Emphasis is placed on the integration of modes and mechanisms of action with functional endpoints that are relevant to human and wildlife health. This book will be a useful resource for toxicologists, environmental chemists, risk assessors, and researchers with an interest in the class of compounds known as perfluoroalkyl and polyfluoroalkyl substances.
650 0 _amedicine.
_9566220
650 0 _apharmacology.
_9460043
650 0 _aEnvironmental Health.
_9315344
650 0 _aEcotoxicology.
_9307759
650 1 4 _aBiomedicine.
_9566246
650 2 4 _aPharmacology/Toxicology.
_9302222
650 2 4 _aEnvironmental Health.
_9315344
650 2 4 _aEcotoxicology.
_9307759
700 1 _aDeWitt, Jamie C.
_eeditor.
_9465672
710 2 _aSpringerLink (Online service)
_9143950
773 0 _tSpringer eBooks
830 0 _aMolecular and Integrative Toxicology,
_9414500
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-319-15518-0
912 _aZDB-2-SBL
999 _c414055