000 04320nam a22004935i 4500
001 vtls000557575
003 RU-ToGU
005 20210922085335.0
007 cr nn 008mamaa
008 170212s2015 gw | s |||| 0|eng d
020 _a9783319090757
_9978-3-319-09075-7
024 7 _a10.1007/978-3-319-09075-7
_2doi
035 _ato000557575
040 _aSpringer
_cSpringer
_dRU-ToGU
050 4 _aHD30.23
072 7 _aKJT
_2bicssc
072 7 _aKJMD
_2bicssc
072 7 _aBUS049000
_2bisacsh
082 0 4 _a658.40301
_223
245 1 0 _aOptimization of Pharmaceutical R&D Programs and Portfolios
_helectronic resource
_bDesign and Investment Strategy /
_cedited by Zoran Antonijevic.
260 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2015.
300 _aVIII, 202 p. 38 illus., 24 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
505 0 _aNeed for Optimal Design of Pharmaceutical Programs and Portfolios in Modern Medical Product Development -- Clinical Aspects of Pharmaceutical Portfolio Management -- Drug Development and the Cost of Capital -- Investment Considerations for Pharmaceutical Product Portfolios -- Challenges of Portfolio Management in Pharmaceutical Development -- Impact of Phase 2b Strategies on Optimization of Drug Development Programs -- Using Decision Analysis to Support the Design of Clinical Trials at a Program Level -- Indication Sequencing for a New Molecular Entity with Multiple Potential Oncology Indications -- Maximizing Return on Investment in Phase II Proof-of-Concept Trials -- Portfolio Optimization of Therapies and Their Predictive Biomarkers -- Dynamically Optimizing Budget Allocation for Phase 3 Drug Development Portfolios Incorporating Uncertainty in the Pipeline.
520 _aVery little has been published on optimization of pharmaceutical portfolios. Moreover, most of the published literature comes from the commercial perspective, where probability of technical success (PoS) is treated as fixed, and not as a consequence of development strategy or design. In this book there is a strong focus on the impact of study design on PoS, and ultimately a portfolio’s value. Design options that are discussed are dose-selection strategies, adaptive design, and enrichment. Some development strategies that are examined are indication sequencing, optimal number of programs, and optimal decision criteria.     This book includes chapters written by authors with very broad backgrounds including financial, clinical, statistical, decision sciences, commercial, and regulatory. Many authors have long held executive positions and have been involved with decision making at a product or at a portfolio level. As such, it is expected that this book will attract a very broad audience, including decision makers in pharmaceutical R&D, commercial, and financial departments. The intended audience also includes portfolio planners and managers, statisticians, decision scientists, and clinicians. Early chapters describe approaches to portfolio optimization from big pharma, and venture capital standpoints, focusing on finances and processes. Later chapters present selected statistical and decision analysis methods for optimizing drug development programs and portfolios. Some methodological chapters are technical; however, with a few exceptions they require a basic knowledge of statistics by a reader. .
650 0 _abusiness.
_9366240
650 0 _aOperations research.
_9303058
650 0 _aDecision making.
_9294514
650 0 _aMathematical optimization.
_9566241
650 0 _aStatistics.
_9124796
650 1 4 _aBusiness and Management.
_9459956
650 2 4 _aOperation Research/Decision Theory.
_9411428
650 2 4 _aoptimization.
_9566242
650 2 4 _aStatistics for Life Sciences, Medicine, Health Sciences.
_9265982
700 1 _aAntonijevic, Zoran.
_eeditor.
_9462761
710 2 _aSpringerLink (Online service)
_9143950
773 0 _tSpringer eBooks
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-319-09075-7
912 _aZDB-2-SBE
999 _c412315