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020 _a9781493921904
_9978-1-4939-2190-4
024 7 _a10.1007/978-1-4939-2190-4
_2doi
035 _ato000556967
040 _aSpringer
_cSpringer
_dRU-ToGU
050 4 _aRC321-580
072 7 _aPSAN
_2bicssc
072 7 _aMED057000
_2bisacsh
082 0 4 _a612.8
_223
245 1 4 _aThe Molecular Basis of Autism
_helectronic resource
_cedited by S. Hossein Fatemi.
260 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2015.
300 _aXVIII, 437 p. 38 illus., 17 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
490 1 _aContemporary Clinical Neuroscience
505 0 _aPreface -- A Brief History of Autism -- Autism Spectrum Disorder: Diagnostic Considerations -- Epidemiologic Features of Autism Spectrum Disorders -- Genetics of Autism Spectrum Disorders: The Opportunity and Challenge in the Genetics Clinic -- Epigenetic Regulation in Autism -- Immunology of Autism -- Neuroimaging in Autism Spectrum Disorders -- The Neuropathology of Autism -- Pharmacology of ASD Spectrum Disorder -- Behavioral Therapies -- Autism and Dopamine -- Autism and Glutamate -- Serotonin in Autism Spectrum Disorder: Insights From Human Studies and Animal Models -- Oxytocin and Vasopressin in Autism and Genetic Syndromes -- Molecular basis of cholinergic changes in autistic spectrum disorders and relevance for treatment interventions -- Reelin, GABA, FMRP, and Autism -- The Role of Neurexins and Neuroligins in Autism -- Neurotrophins, their receptors and autism: ligand vs. receptor abnormalities -- Cognition, Motor Control and Other Aspects of Autism: A Pragmatic Review -- Increased vulnerability to oxidative stress and mitochondrial dysfunction in autism -- Index.
520 _aThis book is a comprehensive overview of the clinical and scientific aspects of Autism from the leading experts in the field. The clinical section covers everything from epidemiological features to epigenetic regulation to behavioral therapies and much in between. The basic science section presents the latest knowledge on the underlying causes of the disorder including the role of various neurotransmitters, neurexins and neuroligins, reelin, and other proteins. Chapters also explore the cognition and motor control in autism and the connection between oxidative stress and mitochondrial dysfunction and autism. The thorough description of these underlying causes may help researchers and clinicians find more effective treatments and therapies for the 1 in 68 American children who have been diagnosed with Autism.
650 0 _amedicine.
_9566220
650 0 _aNeurosciences.
_9302217
650 0 _aPsychiatry.
_9566321
650 0 _aDevelopmental psychology.
_9566366
650 1 4 _aBiomedicine.
_9566246
650 2 4 _aNeurosciences.
_9302217
650 2 4 _aPsychiatry.
_9566321
650 2 4 _aDevelopmental Psychology.
_9566368
700 1 _aFatemi, S. Hossein.
_eeditor.
_9310188
710 2 _aSpringerLink (Online service)
_9143950
773 0 _tSpringer eBooks
830 0 _aContemporary Clinical Neuroscience
_9314005
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4939-2190-4
912 _aZDB-2-SBL
999 _c411519