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_a9781493924806 _9978-1-4939-2480-6 |
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_a10.1007/978-1-4939-2480-6 _2doi |
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| 040 |
_aSpringer _cSpringer _dRU-ToGU |
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_a571.86 _223 |
| 245 | 1 | 0 |
_aCell Signaling During Mammalian Early Embryo Development _helectronic resource _cedited by Henry J. Leese, Daniel R. Brison. |
| 260 |
_aNew York, NY : _bSpringer New York : _bImprint: Springer, _c2015. |
||
| 300 |
_aXII, 216 p. 21 illus., 16 illus. in color. _bonline resource. |
||
| 336 |
_atext _btxt _2rdacontent |
||
| 337 |
_acomputer _bc _2rdamedia |
||
| 338 |
_aonline resource _bcr _2rdacarrier |
||
| 490 | 1 |
_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v843 |
|
| 520 | _aThe book considers signaling events from the zygote embryo through to the blastocyst with relevant data from embryonic stem (ES) cells, including dialogue with the extracellular environment and with the maternal tract during the implantation process. Application of the knowledge described to improve the success of human and animal assisted conception is considered where appropriate, but the focus is largely on fundamental rather than applied cell/molecular biology, as this is the area that has historically been neglected. While the general features of metabolism during preimplantation development are well established, especially in terms of nutrient requirements, uptake and fate, remarkably little is known about early embryo signaling events, intracellular or intercellular, between individual embryos in vitro or with the female reproductive tract in vivo. This contrasts with the wealth of information on cell signaling in somatic cells and tissues, as a glance at any textbook of biochemistry illustrates. This lack of information is such that our understanding of the molecular cell biology of early embryos -- a prerequisite to defining the mechanisms which regulate development at this critical stage of the life cycle -- is seriously incomplete. This volume is the first to address this issue by describing the current state of knowledge on cell signaling during mammalian early embryo development and highlighting priority areas for research. | ||
| 650 | 0 |
_aLife Sciences. _9295653 |
|
| 650 | 0 |
_aReproductive Medicine. _9302989 |
|
| 650 | 0 |
_aCell Biology. _9302220 |
|
| 650 | 0 |
_aEmbryology. _9413371 |
|
| 650 | 1 | 4 |
_aLife Sciences. _9295653 |
| 650 | 2 | 4 |
_aEmbryology. _9413371 |
| 650 | 2 | 4 |
_aCell Biology. _9302220 |
| 650 | 2 | 4 |
_aReproductive Medicine. _9302989 |
| 700 | 1 |
_aLeese, Henry J. _eeditor. _9461264 |
|
| 700 | 1 |
_aBrison, Daniel R. _eeditor. _9461265 |
|
| 710 | 2 |
_aSpringerLink (Online service) _9143950 |
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| 773 | 0 | _tSpringer eBooks | |
| 830 | 0 |
_aAdvances in Experimental Medicine and Biology, _9303385 |
|
| 856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-1-4939-2480-6 |
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| 999 | _c411470 | ||