000 04339nam a22005535i 4500
001 vtls000546552
003 RU-ToGU
005 20210922083644.0
007 cr nn 008mamaa
008 160915s2014 ne | s |||| 0|eng d
020 _a9789401788816
_9978-94-017-8881-6
024 7 _a10.1007/978-94-017-8881-6
_2doi
035 _ato000546552
040 _aSpringer
_cSpringer
_dRU-ToGU
050 4 _aR-RZ
072 7 _aMBGR
_2bicssc
072 7 _aMED000000
_2bisacsh
082 0 4 _a610
_223
245 1 0 _aMACPF/CDC Proteins - Agents of Defence, Attack and Invasion
_helectronic resource
_cedited by Gregor Anderluh, Robert Gilbert.
260 _aDordrecht :
_bSpringer Netherlands :
_bImprint: Springer,
_c2014.
300 _aXI, 329 p. 57 illus., 52 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
490 1 _aSubcellular Biochemistry,
_x0306-0225 ;
_v80
505 0 _aPart I: Overview of MACPF/CDCs -- Introduction: Brief Historical Overview -- Distribution of MACPF/CDC proteins -- Evolution of the Complement System -- Part II: Structures of MACPF/CDCs -- Structural Features of Cholesterol Dependent Cytolysins and Comparison to other MACPF-domain containing proteins -- Perfringolysin O Structure and Mechanism of Pore Formation as a Paradigm for Cholesterol-Dependent Cytolysins -- Structural Biology of the Membrane Attack Complex -- Part III: Functional aspect --  Membrane Interactions and Cellular Effects of MACPF/CDC Proteins -- The Biology of Pneumolysin -- Multifaceted Activity of Listeriolysin O, the Cholesterol-Dependent Cytolysin of Listeria monocytogenes -- Perforin - a Key Pore-Forming Protein for Immune Control of Viruses and Cancer -- Perforin and Human Diseases -- The role of MACPF Proteins in the Biology of Malaria and other Apicomplexan Parasites -- Chlamydial MACPF Protein CT153 -- Fungal MACPF-Like Proteins and Aegerolysins: Bi-Component Pore-Forming Proteins? -- Fluorescence Imaging of MACPF/CDC Proteins: New Techniques and Their Application.
520 _aThis book focusses on evolutionary, structural and functional aspects of pore-forming proteins, bringing together prominent researchers in the fields of structural biology and cellular and biophysical techniques. The focus is on the MACPF/CDC protein superfamily that was originally discovered because of unexpected structural similarity between a domain present in bacterial cholesterol-dependent cytolysins (CDC) and proteins of the membrane attack complex/perforin (MACPF) family. Members of the MACPF/CDC superfamily are crucial for many biological processes, being efficient agents of development, defence, attack and invasion of cells and tissues. However, their best-known role is in bacterial pathogenesis and the proper functioning of the vertebrate immune system, via formation of transmembrane pores in target cell membranes.   The book contains chapters on the distribution of MACPF/CDC proteins and on aspects of their evolution and structural properties, the similarities between different superfamily members and functional properties of some of the best known examples. The book also contains an overview of biophysical approaches that may be used in the future to provide further insights into how these interesting proteins function.  .
650 0 _amedicine.
_9566220
650 0 _aScience (General).
_9191711
650 0 _achemistry.
_9161768
650 0 _aPharmacy.
_9299059
650 0 _aEntomology.
_9312679
650 1 4 _aBiomedicine.
_9566246
650 2 4 _aBiomedicine general.
_9566281
650 2 4 _aMedicine/Public Health, general.
_9265983
650 2 4 _aScience, general.
_9191711
650 2 4 _aChemistry/Food Science, general.
_9303270
650 2 4 _aEntomology.
_9312679
650 2 4 _aPharmacy.
_9299059
700 1 _aAnderluh, Gregor.
_eeditor.
_9455643
700 1 _aGilbert, Robert.
_eeditor.
_9455644
710 2 _aSpringerLink (Online service)
_9143950
773 0 _tSpringer eBooks
830 0 _aSubcellular Biochemistry,
_9304364
856 4 0 _uhttp://dx.doi.org/10.1007/978-94-017-8881-6
912 _aZDB-2-SBL
999 _c404221