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_a9789401780353 _9978-94-017-8035-3 |
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_a10.1007/978-94-017-8035-3 _2doi |
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_aSpringer _cSpringer _dRU-ToGU |
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| 050 | 4 | _aRC261-271 | |
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_aMJCL _2bicssc |
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_aMED062000 _2bisacsh |
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_a614.5999 _223 |
| 100 | 1 |
_aRibatti, Domenico. _eauthor. _9316431 |
|
| 245 | 1 | 0 |
_aAngiogenesis and Anti-Angiogenesis in Hematological Malignancies _helectronic resource _cby Domenico Ribatti. |
| 260 |
_aDordrecht : _bSpringer Netherlands : _bImprint: Springer, _c2014. |
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| 300 |
_aXI, 114 p. 44 illus., 30 illus. in color. _bonline resource. |
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| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bc _2rdamedia |
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| 338 |
_aonline resource _bcr _2rdacarrier |
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| 505 | 0 | _aPreface -- Introduction -- Angiogenesis in multiple myeloma -- Angiogenesis in lymphomas -- Angiogenesis in leukemia -- Antiangiogenesis -- Concluding remarks -- References. | |
| 520 | _aIt has been generally accepted that angiogenesis is involved in the pathogenesis of hematological malignancies, like acute and chronic leukemia, lymphoma, myelodysplastic syndromes, myeloproliferative neoplasms and multiple myeloma. The extent of angiogenesis in the bone marrow has been correlated with disease burden, prognosis and treatment outcome. Reciprocal positive and negative interactions between tumor cells and bone marrow stromal cells, namely hematopoietic stem cells, fibroblasts, osteoblasts/osteoclasts, endothelial cells, endothelial progenitor cells, T cells, macrophages and mast cells, mediated by an array of cytokines, receptors and adhesion molecules, modulate the angiogenic response in hematological tumors. More recently, it has been emphasized the pro-angiogenic role of the so called “vascular niche”, indicating a site rich in blood vessels where endothelial cells and mural cells such as pericytes and smooth muscle cells create a microenvironment that affects the behavior of several stem and progenitor cells, in hematological malignancies. | ||
| 650 | 0 |
_amedicine. _9566220 |
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| 650 | 0 |
_aOncology. _9303086 |
|
| 650 | 0 |
_aHematology. _9307898 |
|
| 650 | 0 |
_aLife Sciences. _9295653 |
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| 650 | 1 | 4 |
_aBiomedicine. _9566246 |
| 650 | 2 | 4 |
_aCancer Research. _9566267 |
| 650 | 2 | 4 |
_aOncology. _9303086 |
| 650 | 2 | 4 |
_aHematology. _9307898 |
| 650 | 2 | 4 |
_aLife Sciences, general. _9303679 |
| 710 | 2 |
_aSpringerLink (Online service) _9143950 |
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| 773 | 0 | _tSpringer eBooks | |
| 856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-94-017-8035-3 |
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| 999 | _c403712 | ||