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020 _a9784431548621
_9978-4-431-54862-1
024 7 _a10.1007/978-4-431-54862-1
_2doi
035 _ato000545788
040 _aSpringer
_cSpringer
_dRU-ToGU
050 4 _aRF1-547
072 7 _aMJP
_2bicssc
072 7 _aMED066000
_2bisacsh
082 0 4 _a617.51
_223
245 1 0 _aRegenerative Medicine for the Inner Ear
_helectronic resource
_cedited by Juichi Ito.
260 _aTokyo :
_bSpringer Japan :
_bImprint: Springer,
_c2014.
300 _aXI, 321 p. 65 illus., 48 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
505 0 _aPart I Targets of Regenerative Medicine for the Inner Ear -- 1 Anatomy of the Inner Ear -- 2 Therapeutic Targets and Possible Strategies for Regenerative Medicine for the Inner Ear -- 3 Hair cell -- 4 Stereocilia -- 5 Cochlear Lateral Wall -- 6 Spiral Ganglion Cell and Auditory Neuron -- 7 Synaptic Contacts between Hair Cells and Primary Neurons -- 8 Otolith -- 9 Tectorial membrane -- Part II Development of the Inner Ear -- 10 Development and regeneration -- 11 Otic Induction -- 12 Cochlear Development -- 13 Vestibular Development -- Part III Cochlear Implants -- 14 Cochlear Implant: Past, Present and Future.- 15 Recent Progress in Cochlear Implant -- 16 Regenerative medicine in cochlear implantation -- 17 Artificial cochlear epithelium -- 18 Auditory Brainstem Implant -- Part IV Hair Cell Regeneration -- 19 Hair Cell Regeneration in the Avian -- 20 Self Repair -- 21 Transdifferentiation -- 22 Dedifferentiation‐mediated Regeneration -- 23 Gene Therapy -- 24 Cell Therapy -- Part V Spiral Ganglion Neuron Regeneration -- 25 Clinical Background -- 26 SGN development -- 27 Gene Therapy for Regeneration and Preservation of Spinal Ganglion Neurons -- 28 Cell therapy -- 29 Afferent dendrite and axon -- Part VI Stem Cells -- 30 Inner ear stem cells -- 31 Pluripotent Stem Cells -- 32 Somatic Stem Cells -- Part VII Future Perspective -- 33 Regenerative Medicine for the Inner Ear ‐ Summary.
520 _aThe research described in this book represents important steps toward understanding the development of inner ear medicine and new perspectives in regenerative medicine, including efficacy in cochlear implants and various other treatments. The book depicts the mechanisms that underlie inner ear diseases, their experimental models, and proposals for new strategies to treat their symptoms. As well, the exciting future prospects for dealing with the very common problem of inner ear diseases are explained. These disorders occur among many people and include sensorineural hearing loss (SNHL), sudden deafness, senile deafness, noise-induced deafness, tinnitus, dizziness–vertigo, and Ménière’s disease. In Japan alone, there are more than 6 million deaf patients including those with middle-range deafness. There is currently no effective treatment, and regardless of the underlying cause, the damage has been considered irreversible. However, the results of recent research show that these patients actually can recover. The study of hair cells, spiral ganglion neurons, and stem cells for inner ear diseases such as SNHL, tinnitus, dizziness, and vertigo is at the forefront of regenerative medicine and may provide solutions to some of these problems. The information presented here makes this book a valuable professional reference work for all doctors and researchers in the field of otolaryngology who focus on regenerative treatments for inner ear diseases.
650 0 _amedicine.
_9566220
650 0 _aGene Therapy.
_9329107
650 0 _aNeurosciences.
_9302217
650 0 _aOtorhinolaryngology.
_9304467
650 0 _aHead
_xSurgery.
_9316459
650 1 4 _aMedicine & Public Health.
_9566221
650 2 4 _aOtorhinolaryngology.
_9304467
650 2 4 _aRegenerative Medicine/Tissue Engineering.
_9413372
650 2 4 _aHead and Neck Surgery.
_9316460
650 2 4 _aGene Therapy.
_9329107
650 2 4 _aNeurosciences.
_9302217
700 1 _aIto, Juichi.
_eeditor.
_9454301
710 2 _aSpringerLink (Online service)
_9143950
773 0 _tSpringer eBooks
856 4 0 _uhttp://dx.doi.org/10.1007/978-4-431-54862-1
912 _aZDB-2-SME
999 _c403510