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008 160915s2014 gw | s |||| 0|eng d
020 _a9783642451171
_9978-3-642-45117-1
024 7 _a10.1007/978-3-642-45117-1
_2doi
035 _ato000544885
040 _aSpringer
_cSpringer
_dRU-ToGU
050 4 _aRM845-862.5
072 7 _aMJCL1
_2bicssc
072 7 _aMED080000
_2bisacsh
082 0 4 _a615.842
_223
100 1 _aAkleyev, Alexander V.
_eauthor.
_9452126
245 1 0 _aChronic Radiation Syndrome
_helectronic resource
_cby Alexander V. Akleyev.
260 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg :
_bImprint: Springer,
_c2014.
300 _aXXI, 410 p. 65 illus., 4 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
505 0 _aDefinition, classification and clinical presentation of Chronic Radiation Syndrome (CRS) associated with total exposure to external gamma-radiation -- Epidemiology of Chronic Radiation Syndrome -- Mechanisms involved in Chronic Radiation exposure effects. Pathogenesis of Chronic Radiation Syndrome -- Pathoanatomy of Chronic Radiation Syndrome during the period of its development and at recovery stage -- Clinical manifestations of Chronic Radiation Syndrome -- Health status in CRS patients during the period of late effects development -- Dynamics of hematopoietic changes in CRS patients -- Diagnosis of Chronic Radiation Syndrome -- Differential diagnosis of Chronic Radiation Syndrome -- Treatment of patients with Chronic Radiation Syndrome -- Rehabilitation and expert evaluation of health status for persons with Chronic Radiation Syndrome.
520 _aThis book covers all aspects of chronic radiation syndrome (CRS) based on observations in a unique sample of residents of the Techa riverside villages in the southern Urals who were exposed to radioactive contamination in the 1950s owing to releases of liquid radioactive wastes from Mayak Production Association, which produced plutonium for weapons. In total, 940 cases of CRS were diagnosed in this population and these patients were subjected to detailed analysis. The opening chapters address the definition and classification of CRS, epidemiology and pathogenesis, covering molecular and cellular mechanisms, radioadaptation, and the role of tissue reactions. The pathoanatomy of CRS during the development and recovery stages is discussed for all organ systems. Clinical manifestations of CRS at the different stages are then described in detail and the dynamics of hematopoietic changes are thoroughly examined. In the following chapters, principles of diagnosis (including assessment of the exposure doses to critical organs) and differential diagnosis from a wide range of other conditions are discussed and current and potential treatment options, described. The medical and social rehabilitation of persons with CRS is also covered. This book, which casts new light on the condition, will be of value for all practitioners and researchers with an interest in CRS.
650 0 _amedicine.
_9566220
650 0 _aRadiotherapy.
_9307053
650 0 _aHematology.
_9307898
650 1 4 _aMedicine & Public Health.
_9566221
650 2 4 _aRadiotherapy.
_9307053
650 2 4 _aHematology.
_9307898
710 2 _aSpringerLink (Online service)
_9143950
773 0 _tSpringer eBooks
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-45117-1
912 _aZDB-2-SME
999 _c402255