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020 _a9783319119854
_9978-3-319-11985-4
024 7 _a10.1007/978-3-319-11985-4
_2doi
035 _ato000544152
040 _aSpringer
_cSpringer
_dRU-ToGU
050 4 _aQP110.G45
072 7 _aMFN
_2bicssc
072 7 _aMED107000
_2bisacsh
072 7 _aSCI029000
_2bisacsh
082 0 4 _a611.01816
_223
245 1 0 _aTranscriptomics in Health and Disease
_helectronic resource
_cedited by Geraldo A. Passos.
260 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2014.
300 _aXVII, 344 p. 44 illus., 34 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
505 0 _aPart 1: Basic Principles of the Transcriptome and its Analysis -- What is the Transcriptome and how it is Evaluated? -- Transcriptome Analysis Throughout RNA-seq -- Identification of Biomarkers and Expression Signatures -- Methods for Gene Co-expression Network Visualization and Analysis -- Posttranscriptional Control During Stem Cells Differentiation -- Transcriptome Analysis During Normal Human Mesenchymal Stem Cell Differentiation -- Part II: Transcriptome in Disease -- Thymus Gene Co-expression Networks: A comparative study in children with and without down syndrome -- Transcriptome Profiling in Autoimmune Diseases -- Expression of DNA Repair and Response to Oxidative Stress Genes in Diabetes Mellitus -- MicroRNAs in Cancer -- Transcriptome Profiling in Chronic Inflammatory Diseases of the Musculoskeletal System -- Transcriptome Profiling in Experimental Inflammatory Arthritis -- Transcriptome in Human Mycoses -- Transcriptomics of the Host-pathogen Interaction in Paracoccidioidomycosis -- Dissecting Tuberculosis through Transcriptomic Studies -- Understanding chagas Disease by Genome and Transcriptome Exploration -- Expression Tests in Actual Clinical Practice: How medically useful is the transcriptome? -- Conclusions -- Index.
520 _aAfter sequencing the human genome a decade ago, researchers have continued their projects, but now to try to better understand how, and when, genes are expressed in health and disease. Efforts have been concentrated on the measurement of the expression of RNA transcripts. In an analogy to the genome, the term "transcriptome" was created to refer to the complete set of RNAs in a cell type or tissue in a particular situation. Transcriptomics is the science that studies this issue and it is a branch of functional genomics. Transcriptomics in Heath and Disease provides a comprehensive overview of the science of transcriptomics initially in health, focusing on the concept of the transcriptome and the main methods to evaluate it. The authors discuss the concept and use of gene expression signatures and transcriptional biomarkers in normal development and diseased tissues and organs. As the transcriptome changes depending on the pathology, there is also a focus on the variations in the gene expression in different diseases such as autoimmune, inflammation, cancer and infections. This book should be very useful for researchers in molecular biology focusing on gene expression, human genetics, immunology, and genomics.
650 0 _amedicine.
_9566220
650 0 _aGene expression.
_9567143
650 0 _aBiochemistry.
_9299060
650 1 4 _aBiomedicine.
_9566246
650 2 4 _aGene Expression.
_9567144
650 2 4 _aBiochemistry, general.
_9566263
700 1 _aPassos, Geraldo A.
_eeditor.
_9450887
710 2 _aSpringerLink (Online service)
_9143950
773 0 _tSpringer eBooks
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-319-11985-4
912 _aZDB-2-SBL
999 _c401582