000 | 04061nam a22004575i 4500 | ||
---|---|---|---|
001 | vtls000544152 | ||
003 | RU-ToGU | ||
005 | 20210922082821.0 | ||
007 | cr nn 008mamaa | ||
008 | 160915s2014 gw | s |||| 0|eng d | ||
020 |
_a9783319119854 _9978-3-319-11985-4 |
||
024 | 7 |
_a10.1007/978-3-319-11985-4 _2doi |
|
035 | _ato000544152 | ||
040 |
_aSpringer _cSpringer _dRU-ToGU |
||
050 | 4 | _aQP110.G45 | |
072 | 7 |
_aMFN _2bicssc |
|
072 | 7 |
_aMED107000 _2bisacsh |
|
072 | 7 |
_aSCI029000 _2bisacsh |
|
082 | 0 | 4 |
_a611.01816 _223 |
245 | 1 | 0 |
_aTranscriptomics in Health and Disease _helectronic resource _cedited by Geraldo A. Passos. |
260 |
_aCham : _bSpringer International Publishing : _bImprint: Springer, _c2014. |
||
300 |
_aXVII, 344 p. 44 illus., 34 illus. in color. _bonline resource. |
||
336 |
_atext _btxt _2rdacontent |
||
337 |
_acomputer _bc _2rdamedia |
||
338 |
_aonline resource _bcr _2rdacarrier |
||
505 | 0 | _aPart 1: Basic Principles of the Transcriptome and its Analysis -- What is the Transcriptome and how it is Evaluated? -- Transcriptome Analysis Throughout RNA-seq -- Identification of Biomarkers and Expression Signatures -- Methods for Gene Co-expression Network Visualization and Analysis -- Posttranscriptional Control During Stem Cells Differentiation -- Transcriptome Analysis During Normal Human Mesenchymal Stem Cell Differentiation -- Part II: Transcriptome in Disease -- Thymus Gene Co-expression Networks: A comparative study in children with and without down syndrome -- Transcriptome Profiling in Autoimmune Diseases -- Expression of DNA Repair and Response to Oxidative Stress Genes in Diabetes Mellitus -- MicroRNAs in Cancer -- Transcriptome Profiling in Chronic Inflammatory Diseases of the Musculoskeletal System -- Transcriptome Profiling in Experimental Inflammatory Arthritis -- Transcriptome in Human Mycoses -- Transcriptomics of the Host-pathogen Interaction in Paracoccidioidomycosis -- Dissecting Tuberculosis through Transcriptomic Studies -- Understanding chagas Disease by Genome and Transcriptome Exploration -- Expression Tests in Actual Clinical Practice: How medically useful is the transcriptome? -- Conclusions -- Index. | |
520 | _aAfter sequencing the human genome a decade ago, researchers have continued their projects, but now to try to better understand how, and when, genes are expressed in health and disease. Efforts have been concentrated on the measurement of the expression of RNA transcripts. In an analogy to the genome, the term "transcriptome" was created to refer to the complete set of RNAs in a cell type or tissue in a particular situation. Transcriptomics is the science that studies this issue and it is a branch of functional genomics. Transcriptomics in Heath and Disease provides a comprehensive overview of the science of transcriptomics initially in health, focusing on the concept of the transcriptome and the main methods to evaluate it. The authors discuss the concept and use of gene expression signatures and transcriptional biomarkers in normal development and diseased tissues and organs. As the transcriptome changes depending on the pathology, there is also a focus on the variations in the gene expression in different diseases such as autoimmune, inflammation, cancer and infections. This book should be very useful for researchers in molecular biology focusing on gene expression, human genetics, immunology, and genomics. | ||
650 | 0 |
_amedicine. _9566220 |
|
650 | 0 |
_aGene expression. _9567143 |
|
650 | 0 |
_aBiochemistry. _9299060 |
|
650 | 1 | 4 |
_aBiomedicine. _9566246 |
650 | 2 | 4 |
_aGene Expression. _9567144 |
650 | 2 | 4 |
_aBiochemistry, general. _9566263 |
700 | 1 |
_aPassos, Geraldo A. _eeditor. _9450887 |
|
710 | 2 |
_aSpringerLink (Online service) _9143950 |
|
773 | 0 | _tSpringer eBooks | |
856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-3-319-11985-4 |
912 | _aZDB-2-SBL | ||
999 | _c401582 |