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020 _a9783319073200
_9978-3-319-07320-0
024 7 _a10.1007/978-3-319-07320-0
_2doi
035 _ato000543467
040 _aSpringer
_cSpringer
_dRU-ToGU
050 4 _aR-RZ
072 7 _aMBGR
_2bicssc
072 7 _aMED000000
_2bisacsh
082 0 4 _a610
_223
245 1 0 _aOxidative Stress and Inflammation in Non-communicable Diseases - Molecular Mechanisms and Perspectives in Therapeutics
_helectronic resource
_cedited by Jordi Camps.
260 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2014.
300 _aVI, 223 p. 50 illus., 34 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
490 1 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v824
505 0 _aOxidation and inflammation, a molecular link between non-communicable diseases.- Oxidative stress and DNA damage in obesity-related tumorigenesis -- High density lipoproteins and ischemia reperfusion injury: The therapeutic potential of HDL to modulate cell survival pathways.- The DING family of phosphate binding proteins in inflammatory diseases -- Inflammation, infection, cancer and all that…The role of paraoxonases -- Autophagy is an inflammation-related defensive mechanism against disease -- Delta-5 and Delta-6 Desaturases: crucial enzymes in polyunsaturated fatty acid-related pathways with pleiotropic influences in health and disease -- Systemic inflammation, intestine and paraoxonase-1.- Serotonin modulation of macrophage polarization: inflammation and beyond -- Energy metabolism and metabolic sensors in stem cells: The metabostem crossroads of aging and cancer -- Molecular promiscuity of plant polyphenols in the management of age-related diseases: far beyond their antioxidant properties -- Postprandial Inflammation: Targeting glucose and lipids -- Dynamic interplay between metabolic syndrome and immunity -- The axis AGE-RAGE-soluble RAGE and oxidative stress in chronic kidney disease -- The chemokine (C-C motif) ligand 2 in neuroinflammation and neurodegeneration.
520 _aOxidative stress and inflammation underpin most diseases; their mechanisms are inextricably linked. For example, chronic inflammation is associated with oxidation, anti-inflammatory cascades are linked to decreased oxidation, increased oxidative stress triggers inflammation, and redox balance inhibits the inflammatory cellular response. Whether or not oxidative stress and inflammation represent the causes or the consequences of cellular pathology, they contribute significantly to the pathogenesis of non-communicable diseases. The incidence of obesity and other related metabolic disturbances are rising, as are age-related diseases due to progressively aging populations. Interrelations between the mechanisms of oxidative stress and of inflammatory signaling and metabolism are, in the broad sense of energy transformation, being increasingly recognized as part of the problem in non-communicable diseases. The book Oxidative Stress and Inflammation in Non-communicable Diseases: Molecular Mechanisms and Perspectives in Therapeutics is an update on the latest research on the molecular basis of non-communicable diseases and the search for possible therapeutic alternatives. The authors of this monograph are experts in their field, and the book as a whole, provides an overview of the biochemical alterations underlying diseases such as cardiovascular disease, cancer, obesity, renal disease, neurological diseases and diabetes, emphasizing those aspects that they share in common. We hope that this book will be useful for researchers in biomedicine, and also for physicians interested in finding the root causes of the disease, as well as for post-graduate students in biochemistry, molecular biology, nutrition or medicine.
650 0 _amedicine.
_9566220
650 1 4 _aBiomedicine.
_9566246
650 2 4 _aBiomedicine general.
_9566281
700 1 _aCamps, Jordi.
_eeditor.
_9449504
710 2 _aSpringerLink (Online service)
_9143950
773 0 _tSpringer eBooks
830 0 _aAdvances in Experimental Medicine and Biology,
_9303385
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-319-07320-0
912 _aZDB-2-SBL
999 _c400772