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020 _a9783319025919
_9978-3-319-02591-9
024 7 _a10.1007/978-3-319-02591-9
_2doi
035 _ato000542315
040 _aSpringer
_cSpringer
_dRU-ToGU
050 4 _aRB155-155.8
050 4 _aQH431
072 7 _aMFN
_2bicssc
072 7 _aMED107000
_2bisacsh
082 0 4 _a611.01816
_223
082 0 4 _a599.935
_223
245 1 0 _aHormones, Intrauterine Health and Programming
_helectronic resource
_cedited by Jonathan R Seckl, Yves Christen.
260 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2014.
300 _aXIV, 189 p. 10 illus., 9 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
490 1 _aResearch and Perspectives in Endocrine Interactions,
_x1861-2253 ;
_v12
505 0 _aForeword -- Early growth and later health: findings from the Helsinki Birth Cohort Study by Johan G. Eriksson -- Male and female placentas have divergent transcriptomic and epigenomic responses to maternal diets: not just hormones by Anne Gabory, Alexandre Vigé, Jean Lesage, Isabelle Fajardy, Laure Ferry, Linda Attig, Anne Vambergue, Didier Vieau, Jean-Philippe Jais, Luc Jouneau, and Claudine Junien -- Glucocorticoids and fetal programming; necessary and sufficient? By Jonathan R. Seckl -- Developmental programming and the placenta: focusing in on glucocorticoids by Caitlin S. Wyrwoll -- Maternal stress and in utero programming by Louise C. Kenny, Claire Everard and Ali S. Khashan -- Developmental epigenetics and risks of later non-communicable disease by M.A. Hanson, P.D. Gluckman  and K.M. Godfrey -- Epigenetic effects of extreme intrauterine growth in humans by John M. Greally -- The Role of the Placenta in Fetal Programming by John Challis, Debora Sloboda, Shaofu Li, Thorsten Braun, Frank Bloomfield, Ghazala Begum, Anne White, Felice Petraglia, John Newnham -- Developmental Origins of Diabetes: The Role of Epigenetics by Rebecca A. Simmons -- Glucocorticoids, programming and the transmission of effects across generations by Amanda J. Drake -- Subject index.
520 _aThe environment of the fetus in the womb is emerging as a key determinant not only of its immediate status but also of the offspring’s long-term well-being. This largely started with reports of striking epidemiological associations between lower, but still normal, birth weight and a marked increase in the incidence of cardiac, metabolic and neuropsychiatric disorders from childhood to senescence. In seeking to explain these observations, collectively referred to as ‘developmental programming,’ a new subfield of biology has emerged. Major discoveries include detailing the etiological roles of maternal factors such as nutrition, inflammatory disease, stress and psychopathology. Key biochemical mediators have been discovered, notably including hormones such as glucocorticoids, which act on both the fetus and the placenta to change the trajectory of growth, tissue maturation and the expression of specific genes in affected cells. Such persisting changes in the transcription of genes may be in part underpinned by epigenetic changes. The mechanisms of these effects are beginning to emerge and offer the prospect of new diagnostics, biomarkers and potential therapeutic targets. This work provides an accessible and cutting-edge view of this rapidly emerging field.
650 0 _amedicine.
_9566220
650 0 _aHuman genetics.
_9566248
650 0 _aObstetrics.
_9306262
650 0 _aEndocrinology.
_9303589
650 1 4 _aBiomedicine.
_9566246
650 2 4 _aHuman Genetics.
_9566249
650 2 4 _aEndocrinology.
_9303589
650 2 4 _aObstetrics/Perinatology.
_9306263
700 1 _aSeckl, Jonathan R.
_eeditor.
_9448349
700 1 _aChristen, Yves.
_eeditor.
_9316510
710 2 _aSpringerLink (Online service)
_9143950
773 0 _tSpringer eBooks
830 0 _aResearch and Perspectives in Endocrine Interactions,
_9316512
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-319-02591-9
912 _aZDB-2-SBL
999 _c400108