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008 160915s2014 gw | s |||| 0|eng d
020 _a9783319007441
_9978-3-319-00744-1
024 7 _a10.1007/978-3-319-00744-1
_2doi
035 _ato000541911
040 _aSpringer
_cSpringer
_dRU-ToGU
050 4 _aQH505
072 7 _aPHVN
_2bicssc
072 7 _aPSF
_2bicssc
072 7 _aSCI009000
_2bisacsh
082 0 4 _a571.4
_223
100 1 _aRadmaneshfar, Elahe.
_eauthor.
_9447839
245 1 0 _aMathematical Modelling of the Cell Cycle Stress Response
_helectronic resource
_cby Elahe Radmaneshfar.
260 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2014.
300 _aXV, 109 p. 36 illus., 29 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
490 1 _aSpringer Theses, Recognizing Outstanding Ph.D. Research,
_x2190-5053
505 0 _aA biological overview of the cell cycle and its response to osmotic stress and the α-factor -- ODE model of the cell cycle response to osmotic stress -- Boolean model of the cell cycle response to stress -- Conclusion -- List of equations, parameters and initial conditions -- Effect of methods of update on existence of fixed points.
520 _aThe cell cycle is a sequence of biochemical events that are controlled by complex but robust molecular machinery. This enables cells to achieve accurate self-reproduction under a broad range of conditions. Environmental changes are transmitted by molecular signaling networks, which coordinate their actions with the cell cycle.   This work presents the first description of two complementary computational models describing the influence of osmotic stress on the entire cell cycle of S. cerevisiae. Our models condense a vast amount of experimental evidence on the interaction of the cell cycle network components with the osmotic stress pathway. Importantly, it is only by considering the entire cell cycle that we are able to make a series of novel predictions which emerge from the coupling between the molecular components of different cell cycle phases.   The model-based predictions are supported by experiments in S. cerevisiae and, moreover, have recently been observed in other eukaryotes. Furthermore our models reveal the mechanisms that emerge as a result of the interaction between the cell cycle and stress response networks.
650 0 _aphysics.
_9566227
650 0 _aBioinformatics.
_9303853
650 0 _aCell cycle.
_9446273
650 0 _aPhysiology
_xMathematics.
_9307170
650 1 4 _aPhysics.
_9566228
650 2 4 _aPhysics of the Cell.
_9447840
650 2 4 _aCell Cycle Analysis.
_9446274
650 2 4 _aPhysiological, Cellular and Medical Topics.
_9307171
650 2 4 _aComputational Biology/Bioinformatics.
_9306755
650 2 4 _aComplex Networks.
_9411427
710 2 _aSpringerLink (Online service)
_9143950
773 0 _tSpringer eBooks
830 0 _aSpringer Theses, Recognizing Outstanding Ph.D. Research,
_9567110
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-319-00744-1
912 _aZDB-2-PHA
999 _c399822