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020 _a9781493914265
_9978-1-4939-1426-5
024 7 _a10.1007/978-1-4939-1426-5
_2doi
035 _ato000541685
040 _aSpringer
_cSpringer
_dRU-ToGU
050 4 _aRC321-580
072 7 _aPSAN
_2bicssc
072 7 _aMED057000
_2bisacsh
082 0 4 _a612.8
_223
245 1 0 _aExtrasynaptic GABAA Receptors
_helectronic resource
_cedited by Adam C. Errington, Giuseppe Di Giovanni, Vincenzo Crunelli.
260 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2014.
300 _aIX, 295 p. 34 illus., 18 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
490 1 _aThe Receptors ;
_v27
505 0 _aA brief introduction to extrasynaptic GABAA receptors and ‘tonic’ GABAA receptor mediated inhibition in physiology and disease -- Extrasynaptic GABAA receptors: subunit composition, distribution, and regulation -- Biophysical properties of recombinant 2- AND δ- subunit containing GABAA receptors -- The pharmacology of extrasynaptic GABAA receptors -- Neurosteroids and extrasynaptic GABAA receptors -- Sources of GABA that activate extrasynaptic GABAA receptors -- Modulation of Extrasynaptic GABAA Receptors by G-protein-coupled Receptors -- Extrasynaptic GABAA receptors and tonic inhibition in spinal cord -- The role of peri-synaptic GABA receptors after stroke -- The role of extrasynaptic GABAA receptors in focal epilepsy -- Gain-of-Function of Thalamic Extrasynaptic GABA-A Receptors in Typical Absence Seizures -- GABAergic control of the hypothalamic-pituitary-adrenal (HPA) axis: role of extrasynaptic GABAA receptors -- Tonic GABAA receptor mediated inhibition in Fragile-X Syndrome: A cause of dysfunction or a pathway for a cure?
520 _aGABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed “tonic” inhibition, has been described. Whereas synaptic GABAA receptors underlie classical “phasic” GABAA receptor-mediated inhibition (inhibitory postsynaptic currents), tonic GABAA receptor-mediated inhibition results from the activation of extrasynaptic receptors by low concentrations of ambient GABA. Extrasynaptic GABAA receptors are composed of receptor subunits that convey biophysical properties ideally suited to the generation of persistent inhibition and are pharmacologically and functionally distinct from their synaptic counterparts. This book highlights ongoing work examining the properties of recombinant and native extrasynaptic GABAA receptors and their preferential targeting by endogenous and clinically relevant agents. In addition, it emphasizes the important role of extrasynaptic GABAA receptors in GABAergic inhibition throughout the CNS and identifies them as a major player in both physiological and pathophysiological processes.
650 0 _amedicine.
_9566220
650 0 _aNeurosciences.
_9302217
650 0 _aToxicology.
_9302218
650 0 _aNeurology.
_9303067
650 1 4 _aBiomedicine.
_9566246
650 2 4 _aNeurosciences.
_9302217
650 2 4 _aPharmacology/Toxicology.
_9302222
650 2 4 _aNeurology.
_9303067
700 1 _aErrington, Adam C.
_eeditor.
_9447568
700 1 _aDi Giovanni, Giuseppe.
_eeditor.
_9447569
700 1 _aCrunelli, Vincenzo.
_eeditor.
_9447570
710 2 _aSpringerLink (Online service)
_9143950
773 0 _tSpringer eBooks
830 0 _aThe Receptors ;
_9313971
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4939-1426-5
912 _aZDB-2-SBL
999 _c399669