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020 _a9781493920952
_9978-1-4939-2095-2
024 7 _a10.1007/978-1-4939-2095-2
_2doi
035 _ato000541730
040 _aSpringer
_cSpringer
_dRU-ToGU
050 4 _aR-RZ
072 7 _aMBGR
_2bicssc
072 7 _aMED000000
_2bisacsh
082 0 4 _a610
_223
245 1 2 _aA Systems Biology Approach to Blood
_helectronic resource
_cedited by Seth Joel Corey, Marek Kimmel, Joshua N. Leonard.
260 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2014.
300 _aIX, 403 p. 73 illus., 52 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
490 1 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v844
505 0 _aPart I: Basic Components -- Systems Hematology:  An Introduction -- Quantification and Modeling of Stem Cell - Niche Interaction -- Angiogenesis: A Systems Biology View of Blood Vessel Remodeling -- Erythropoiesis: From Molecular Pathways to System Properties -- Systems Biology of Megakaryocytes -- Systems Biology of Platelet-Vessel Wall Interactions -- Systems Approach to Phagoycte Production and Activation: Neutrophils and Monocytes -- Part II: Physiological Processes -- Stochasticity and Determinism in Models of Hematopoiesis -- Systems Analysis of High–Throughput Data -- Developing a Systems-Based Understanding of Hematopoietic Stem Cell Cycle Control -- A Systems Biology Approach to Iron Metabolism -- Innate Immunity in Disease - Insights from Mathematical Modeling and Analysis -- Modeling Biomolecular Site Dynamics in Immunoreceptor Signaling Systems -- Structure and Function of Platelet Receptors Initiating Blood Clotting -- Part III: Clinical Applications -- Understanding and Treating Cytopenia through Mathematical Modeling -- Drug Resistance -- Etiology and Treatment of Hematological Neoplasms: Stochastic Mathematical Models -- Assessing Hematopoietic (Stem-) Cell Behavior during Regenerative Pressure -- Engineered Cell-Based Therapies: A Vanguard of Design-Driven Medicine -- Part IV: Epilogue -- A Systems Approach to Blood Disorders -- Index.
520 _aThe blood system is multi-scale, from the organism to the organs to cells to intracellular signaling pathways to macromolecule interactions. Blood consists of circulating cells, cellular fragments (platelets and microparticles), and plasma macromolecules. Blood cells and their fragments result from a highly-ordered process, hematopoiesis. Definitive hematopoiesis occurs in the bone marrow, where pluripotential stem cells give rise to multiple lineages of highly specialized cells. Highly-productive and continuously regenerative, hematopoiesis requires a microenvironment of mesenchymal cells and blood vessels. A Systems Biology Approach to Blood is divided into three main sections: basic components, physiological processes, and clinical applications. Using blood as a window, one can study health and disease through this unique tool box with reactive biological fluids that mirrors the prevailing hemodynamics of the vessel walls and the various blood cell types. Many blood diseases, rare and common can and have been exploited using systems biology approaches with successful results and therefore ideal models for systems medicine. More importantly, hematopoiesis offers one of the best studied systems with insight into stem cell biology, cellular interaction, development; linage programing and reprograming that are every day influenced by the most mature and understood regulatory networks.
650 0 _amedicine.
_9566220
650 0 _aHematology.
_9307898
650 0 _aBiological models.
_9332680
650 1 4 _aBiomedicine.
_9566246
650 2 4 _aBiomedicine general.
_9566281
650 2 4 _aSystems Biology.
_9332681
650 2 4 _aHematology.
_9307898
700 1 _aCorey, Seth Joel.
_eeditor.
_9447291
700 1 _aKimmel, Marek.
_eeditor.
_9319753
700 1 _aLeonard, Joshua N.
_eeditor.
_9447292
710 2 _aSpringerLink (Online service)
_9143950
773 0 _tSpringer eBooks
830 0 _aAdvances in Experimental Medicine and Biology,
_9303385
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4939-2095-2
912 _aZDB-2-SBL
999 _c399531