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008 160915s2014 xxu| s |||| 0|eng d
020 _a9781461480396
_9978-1-4614-8039-6
024 7 _a10.1007/978-1-4614-8039-6
_2doi
035 _ato000540934
040 _aSpringer
_cSpringer
_dRU-ToGU
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
245 1 0 _aNuclear Signaling Pathways and Targeting Transcription in Cancer
_helectronic resource
_cedited by Rakesh Kumar.
260 _aNew York, NY :
_bSpringer New York :
_bImprint: Humana Press,
_c2014.
300 _aXII, 439 p. 56 illus., 52 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
490 1 _aCancer Drug Discovery and Development,
_x2196-9906
505 0 _aPreface -- Steroid Receptor Coactivators (SRCs) as Integrators of Multiple Signaling Pathways in Cancer Progression -- Role of Alteration/Deficiency in Activation (ADA) Complex in the Cell Cycle, Genomic Instability and Cancer -- RUNX2 Transcriptional Regulation in Development and Disease -- Epigenetic Mechanisms of Cancer Metastasis -- Regulatory Effects of Arsenic on Cellular Signaling Pathways: Biological Effects and Therapeutic Implications -- Nuclear Factors Linking Cancer and Inflammation -- Regulation of the Jak/STATs Pathways by Histone Deacetylases -- Receptor Tyrosine Kinases in the Nucleus: Nuclear Functions and Therapeutic Implications in Cancers -- Nucleolar Signaling Determines Cell Fate – The RP-Mdm2-p53 Axis Fine-Tunes Cellular Homeostasis -- Transcriptional Regulation of Lipogenesis as a Therapeutic Target for Cancer Treatment -- Selective Inhibition of Acetyl-Lysine Effector Domains of the Bromodomain Family in Oncology -- Domain Specific Targeting of Cancer -- The Potential of Targeting Splicing for Cancer Therapy -- Exploiting Cell Cycle Pathways in Cancer Therapy: New (and Old) Targets and Potential Strategies -- Histone Demethylases in Prostate Cancer -- Therapeutic Significance of Chromatin Remodeling Complexes in Cancer -- Index.
520 _aThis book presents the most up-to-date information in the area of targeted therapeutics with a particular focus on pathway-centered approaches and transcription by leading authorities in molecular cancer research. The goal is to cover several critical principles of cancer therapeutics, ranging from regulation of cancer associated genes by coregulators, cancer cell signaling, modifiers of epigenome functionality and specific protein domains, and emerging significance of splicing. The book is directed for basic and translational scientists, clinicians, clinical investigators, fellows, residents, graduate students, and educators in the areas of molecular therapeutics and cancer medicine, and medical sciences at-large. Readers will be able to grasp the overall importance of the pathway, associated pathobiology and clinical manifestation, and possible points of intervention with a goal to solidify new cancer therapeutic targets.
650 0 _amedicine.
_9566220
650 0 _aOncology.
_9303086
650 0 _aToxicology.
_9302218
650 1 4 _aBiomedicine.
_9566246
650 2 4 _aCancer Research.
_9566267
650 2 4 _aPharmacology/Toxicology.
_9302222
700 1 _aKumar, Rakesh.
_eeditor.
_9446428
710 2 _aSpringerLink (Online service)
_9143950
773 0 _tSpringer eBooks
830 0 _aCancer Drug Discovery and Development,
_9310493
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-8039-6
912 _aZDB-2-SBL
999 _c399030