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020 _a9781447163503
_9978-1-4471-6350-3
024 7 _a10.1007/978-1-4471-6350-3
_2doi
035 _ato000540681
040 _aSpringer
_cSpringer
_dRU-ToGU
050 4 _aRC681-688.2
072 7 _aMJD
_2bicssc
072 7 _aMED010000
_2bisacsh
082 0 4 _a616.12
_223
245 1 0 _aMolecular Biology of Valvular Heart Disease
_helectronic resource
_cedited by Nalini M. Rajamannan.
260 _aLondon :
_bSpringer London :
_bImprint: Springer,
_c2014.
300 _aXVII, 150 p. 60 illus., 50 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
505 0 _aCalcific Aortic Valve Disease: The Role of the Stem Cell Niche -- In vitro Cell Culture Model of Calcification: Molecular Regulation of Myofibroblast Differentiation to an Osteoblast Phenotype -- Aortic Valve Apoptosis, Cell Proliferation and Atherosclerosis in Experimental Hypercholesterolemia -- Experimental Model of Aortic Valve Calcification to Induce Osteoblast Differentiation -- Development of an Experimental Model of Mitral Valve Regurgitation via Hypertrophic Chondrocytes -- Testing Drug Eluting Paclitaxel Balloon Valvuloplasty in an Experimental Model of Aortic Stenosis -- Ex vivo model for Bioprosthetic Valve Calcification via Stem Cell Differentiation -- Experimental Hypercholesterolemia in Genetic ApoE-/-/Lrp5-/- Mice: Proof of Principle -- Wnt3a-Lrp5 mediated Bicuspid Aortic Valve Disease -- Mouse Models of Calcific Aortic Valve Disease -- Hemodynamic Mechanisms of Bicuspid Aortic Valve Calcification and Aortopathy -- Bioreactor and biomaterial platforms for investigation of mitral valve biomechanics and mechanobiology -- Identification of early pathological events in calcific aortic valve disease by molecular imaging -- Role of ectonucleotidases and purinergic receptors in calcific aortic valve disease -- In vitro model of Drug Testing -- Application of the LDL-Density-Pressure Theory: The Mitral Valve -- Application of The LDL-Density-Radius Theory: The Aortic Valve.
520 _aThis book presents the cellular details and the basic molecular biology approaches for understanding cardiac valvular disease. It provides novel cellular targets for developing future clinical trials and comprehensive clinical discussion of this expanding field. Molecular Biology of Valvular Heart Disease will guide physicians on the potential medical therapies to treat valvular heart disease while providing a platform for cellular targeting of valvular heart disease. Residents and fellows in cardiology, interventional cardiology, cardiac surgery, and current and future valve biologists alike will find this book to be an invaluable resource for developing further interest and understanding of the cellular basis for cardiac valvular disease treatment.
650 0 _amedicine.
_9566220
650 0 _aCardiology.
_9302215
650 1 4 _aMedicine & Public Health.
_9566221
650 2 4 _aCardiology.
_9302215
700 1 _aRajamannan, Nalini M.
_eeditor.
_9445353
710 2 _aSpringerLink (Online service)
_9143950
773 0 _tSpringer eBooks
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4471-6350-3
912 _aZDB-2-SME
999 _c398415