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020 _a9781447163800
_9978-1-4471-6380-0
024 7 _a10.1007/978-1-4471-6380-0
_2doi
035 _ato000540691
040 _aSpringer
_cSpringer
_dRU-ToGU
050 4 _aRC346-429.2
072 7 _aMJN
_2bicssc
072 7 _aMED056000
_2bisacsh
082 0 4 _a616.8
_223
245 1 0 _aNeurodegenerative Diseases
_helectronic resource
_bClinical Aspects, Molecular Genetics and Biomarkers /
_cedited by Daniela Galimberti, Elio Scarpini.
260 _aLondon :
_bSpringer London :
_bImprint: Springer,
_c2014.
300 _aXIX, 253 p. 15 illus., 9 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
505 0 _aGenetics and Epigenetics: Basic Concepts -- Alzheimer’s Disease: Clinical Aspects and Treatments -- Autosomal Dominant Alzheimer’s Disease: Underlying Causes -- Genetic Risk Factors for Alzheimer’s Disease -- The Role of Cerebrovascular Disease in Cognitive Disease -- Non-genetic Risk Factors for Alzheimer’s disease -- Frontotemporal Lobar Degeneration: Genetics and Clinical Phenotypes -- Alzheimer’s Disease and Frontotemporal Lobar Degeneration: Mouse Models -- Cerebrospinal Fluid Biomarkers in Alzheimer’s Disease and Frontotemporal Dementia -- Biomarkers for Alzheimer’s Disease and Frontotemporal Lobar Degeneration: Imaging -- Amyotrophic Lateral Sclerosis: Genotypes and Phenotypes -- Uncommon Dementias -- Neurodevelopment Alterations, Neurodegeneration and Immunoinflammatory Patterns in the Pathophysiology of Schizophrenia -- Neurodegeneration and Multiple Sclerosis.
520 _aThis book gives an overview of the current knowledge on the most common neurodegenerative diseases, including Alzheimer’s disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and additional neurodegenerative diseases. Different aspects of each disease are reviewed, including clinical issues, treatments, basic discoveries (genetics and molecular biology), and translation of basic research into biomarkers for early diagnosis. In addition, emerging data indicate that neurodegeneration seems to also be present in classically non-degenerative disorders. Therefore, a chapter about overlapping mechanisms between dementias and psychiatric disorders is included, as well as a description of the role of neurodegeneration in multiple sclerosis.   Neurodegenerative Diseases is aimed at clinicians, particularly those working in academic hospitals. This multidisciplinary book will also be of interest to basic researchers in medical fields.
650 0 _amedicine.
_9566220
650 0 _aHuman genetics.
_9566248
650 0 _aNeurosciences.
_9302217
650 0 _aNeurology.
_9303067
650 1 4 _aMedicine & Public Health.
_9566221
650 2 4 _aNeurology.
_9303067
650 2 4 _aNeurosciences.
_9302217
650 2 4 _aHuman Genetics.
_9566249
700 1 _aGalimberti, Daniela.
_eeditor.
_9444823
700 1 _aScarpini, Elio.
_eeditor.
_9444824
710 2 _aSpringerLink (Online service)
_9143950
773 0 _tSpringer eBooks
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4471-6380-0
912 _aZDB-2-SME
999 _c398023