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020 _a9789400756786
_9978-94-007-5678-6
024 7 _a10.1007/978-94-007-5678-6
_2doi
035 _ato000485812
040 _aSpringer
_cSpringer
_dRU-ToGU
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
100 1 _aParat, Marie-Odile.
_eeditor.
_9415982
245 1 0 _aMorphine and Metastasis
_helectronic resource
_cedited by Marie-Odile Parat.
260 _aDordrecht :
_bSpringer Netherlands :
_bImprint: Springer,
_c2013.
300 _aV, 146 p. 20 illus., 16 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
505 0 _a1 Morphine and metastasis: from bench to bedside -- 2 Interaction of Naloxone and Estrogen Receptor in Breast Cancer -- 3 Morphine and immunosuppression in the context of tumor growth and metastasis -- 4 Opioid Regulation of Vascular Integrity -- 5 Iatrogenic Angiogenesis -- 6 Could opioids affect cancer recurrence or metastases? Current experimental and Translational Evidence -- 7 Genetic polymorphisms in the ยต-opioid receptor gene and breast cancer survival -- 8 Anaesthetic and pain management technique in long term cancer outcome - benefits of regional anaesthesia and analgesia in the context of cancer surgery -- 9 Perioperative morphine and cancer recurrence.
520 _aThe possibility that morphine and other opioids may modulate tumour growth and metastasis has been researched for many years. The recent past has seen multiple clinical studies attempting to document whether limiting the perioperative use of morphine is beneficial for cancer surgery patients. Furthermore, a lot of exciting new data has been generated in vitro, but also in preclinical and clinical studies, that indirectly shed light on the effect of opioids on cancer. This book combines chapters written by qualified experts around the world whose research encompasses the effect of morphine or other opioids on tumour growth and metastasis. This includes clinicians, researchers working on animal models and studying the effect of morphine on tumours, and most importantly the mechanism for this effect, and lastly cell biologists. Current investigations and cross talk between basic science and clinical trials will refine our understanding of the multiple levels of actions of morphine and other opioids on tumour growth and metastasis, and result in improved guidelines for patient care. This book will be of interest to clinicians, especially those dealing with cancer patients and their pain management, as well as students, teachers and scientists in the fields of anaesthesiology, oncology, tumour biology, immunology, opioid pharmacology.
650 0 _amedicine.
_9566220
650 0 _aOncology.
_9303086
650 0 _aToxicology.
_9302218
650 0 _aPharmacy.
_9299059
650 0 _aPain Medicine.
_9304219
650 1 4 _aBiomedicine.
_9566246
650 2 4 _aCancer Research.
_9566267
650 2 4 _aPharmacy.
_9299059
650 2 4 _aPharmacology/Toxicology.
_9302222
650 2 4 _aPain Medicine.
_9304219
650 2 4 _aOncology.
_9303086
710 2 _aSpringerLink (Online service)
_9143950
773 0 _tSpringer eBooks
856 4 0 _uhttp://dx.doi.org/10.1007/978-94-007-5678-6
912 _aZDB-2-SBL
999 _c357601