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008 140715s2013 xxu| s |||| 0|eng d
020 _a9781627034562
_9978-1-62703-456-2
024 7 _a10.1007/978-1-62703-456-2
_2doi
035 _ato000484029
040 _aSpringer
_cSpringer
_dRU-ToGU
050 4 _aQH573-671
072 7 _aPSF
_2bicssc
072 7 _aSCI049000
_2bisacsh
082 0 4 _a571.6
_223
100 1 _aLee, Nikki P.
_eeditor.
_9414702
245 1 0 _aNew Advances on Disease Biomarkers and Molecular Targets in Biomedicine
_helectronic resource
_cedited by Nikki P. Lee, C.Y. Cheng, John M. Luk.
260 _aTotowa, NJ :
_bHumana Press :
_bImprint: Humana Press,
_c2013.
300 _aXII, 275 p. 34 illus., 29 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
505 0 _aNon-receptor Protein Kinases c-Src, c-Yes and FAK are Biomarkers for Male Contraceptive Research -- Ankyrin Repeat and Suppressor of Cytokine Signaling Box (ASB) Family Members for Cancer Diagnosis, Prognosis, and Treatment -- MicroRNA as Cancer Biomarkers and Targets -- Oncofetal Molecules as Biomarkers and Drug Targets for Hepatic Cancer -- Ion channels as novel pancreatic cancer biomarkers and targets -- Circulating Biomarkers for Sophageal Squamous Cell Carcinoma -- Using Genomic Biomarkers to Predict Patient Prognosis and Treatment Response in Gastric Cancer -- CARF Regulates Cellular Senescence and Apoptosis by p53 Dependant and Independent Pathways -- Targeting Cancer Metabolisms -- Modulation of Autophagy as a Novel Cancer Therapeutic Strategy -- Functional proteomics screening for novel anti-viral drug targets -- Identification of Tumor Antigens as Targets for Novel Anti-tumor Therapies -- Mesoporous Silica Nanoparticles for Cancer Therapy -- Chemoresistance in Glioma.
520 _aRising occurrences of various diseases and epidemics have pressurized the already-burdened health system across the globe, and this imposes an unprecedented challenge on our current research in identifying disease-specific biomarkers and molecular targets, in particular for cancers, neurological disorders and unexplained infertility. Despite decades of efforts in deciphering the fundamental biology underlying various diseases at discrete levels using an array of advanced technologies, attempts to identify reliable and disease-indicating markers for detection and biomolecules or cellular structures for targeting are still in vain. This monograph describes and discusses the updated findings in this field with a specific aim to compile prior and recent literature and from there to acquire some insights to facilitate future research to expand our options of understanding, detecting and treating diseases. Among the many possible areas of biomedical research, this content comprises two themes: disease biomarkers and molecular targets. We also cover topics that are more advanced in development to emerging scientific discoveries. In particular, we have included in this monograph concepts on the renovated use of oncofetal molecules in cancer prediction and treatment, the evolving development in cancer biology at the cellular and molecular levels and the recent involvement on new classes of molecules in diseases. We hope that this book can renew established concepts in the field, and at the same time lead to important insights for research and development of drugs, diagnostics, and interventions for managing diseases of unmet medical needs.
650 0 _aLife Sciences.
_9295653
650 0 _aOncology.
_9303086
650 0 _aToxicology.
_9302218
650 0 _aCytology.
_9269442
650 1 4 _aLife Sciences.
_9295653
650 2 4 _aCell Biology.
_9302220
650 2 4 _aCancer Research.
_9566267
650 2 4 _aPharmacology/Toxicology.
_9302222
700 1 _aCheng, C.Y.
_eeditor.
_9414703
700 1 _aLuk, John M.
_eeditor.
_9414704
710 2 _aSpringerLink (Online service)
_9143950
773 0 _tSpringer eBooks
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-62703-456-2
912 _aZDB-2-SBL
999 _c356865