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008 140715s2013 xxu| s |||| 0|eng d
020 _a9781461476900
_9978-1-4614-7690-0
024 7 _a10.1007/978-1-4614-7690-0
_2doi
035 _ato000483898
040 _aSpringer
_cSpringer
_dRU-ToGU
050 4 _aR-RZ
072 7 _aMBGR
_2bicssc
072 7 _aMED000000
_2bisacsh
082 0 4 _a610
_223
100 1 _aSelvarajoo, Kumar.
_eauthor.
_9414680
245 1 0 _aImmuno Systems Biology
_h[electronic resource] :
_bA macroscopic approach for immune cell signaling /
_cby Kumar Selvarajoo.
260 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2013.
300 _aIX, 146 p. 69 illus., 61 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
490 1 _aSystems Biology,
_x2191-222X ;
_v3
505 0 _aPreface -- Systems biology of population cell response -- Perturbation-response approach for biological network analysis -- Basics of the mammalian immune system -- Inferring novel features of the TLR4 pathways -- Signaling Flux Redistribution -- Investigating the TLR3 signaling dynamics -- Understanding TNFR1 signaling dynamics -- TRAIL signaling in cancer -- Stochasticity and variability: insights from single cell dynamics -- Investigating single cell stochasticity in TRAIL signaling -- The distinction between single cell and population dynamics -- Finding chaos in biology -- Concluding remarks -- Index.
520 _aTechnological advances of modern biology have generated high volumes of ‘omics’ data. The natural precedence has been to put the complex information together, so that it will lead to spectacular scientific discoveries and medical breakthroughs. In this light, tremendous efforts worldwide are reshaping biological research by integrating with information science. Despite the ‘systems biology’ efforts, for major illnesses, such as proinflammatory diseases and cancer, there is clear clinical evidence that even the most current therapies, at best, control transient response and subdue to the robust adaptability of the disease state. Hence, there is a need for system-levels understanding of bio-complexity. Kumar Selvarajoo brings attention to fundamental questions governing sophisticated behaviors of the mammalian immune system. To tackle some of the complex issues, the book introduces perturbation-response approach, using the law of physics (mass flow conservation), as a means to interpret the dynamic response of major proinflammatory pathways of the immune and cancer cells. Overall, the book provides an illustrated journey that explains biological cell signaling in simple terms.
650 0 _amedicine.
_9566220
650 0 _aImmunology.
_9303380
650 0 _aBioinformatics.
_9303853
650 0 _aBiological models.
_9332680
650 0 _aCytology.
_9269442
650 1 4 _aBiomedicine.
_9566246
650 2 4 _aBiomedicine general.
_9566281
650 2 4 _aSystems Biology.
_9332681
650 2 4 _aBioinformatics.
_9303853
650 2 4 _aComputational Biology/Bioinformatics.
_9306755
650 2 4 _aImmunology.
_9303380
650 2 4 _aCell Biology.
_9302220
710 2 _aSpringerLink (Online service)
_9143950
773 0 _tSpringer eBooks
830 0 _aSystems Biology,
_9414681
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-7690-0
912 _aZDB-2-SBL
999 _c356856