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| 008 | 140715s2013 gw | s |||| 0|eng d | ||
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_a9783319015569 _9978-3-319-01556-9 |
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_a10.1007/978-3-319-01556-9 _2doi |
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_aSpringer _cSpringer _dRU-ToGU |
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_aSCI013010 _2bisacsh |
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_a543 _223 |
| 100 | 1 |
_aHuber, Eva Maria. _eauthor. _9414614 |
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| 245 | 1 | 0 |
_aStructural and Functional Characterization of the Immunoproteasome _helectronic resource _cby Eva Maria Huber. |
| 260 |
_aCham : _bSpringer International Publishing : _bImprint: Springer, _c2013. |
||
| 300 |
_aXIX, 82 p. 33 illus., 29 illus. in color. _bonline resource. |
||
| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bc _2rdamedia |
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| 338 |
_aonline resource _bcr _2rdacarrier |
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| 490 | 1 |
_aSpringer Theses, Recognizing Outstanding Ph.D. Research, _x2190-5053 |
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| 505 | 0 | _aIntroduction -- Objective -- Materials and Methods -- Results -- Discussion -- Appendix. | |
| 520 | _aIn this acclaimed thesis, Eva Maria Huber reveals ground-breaking results by elucidating the crystal structure of the murine immunoproteasome in complex with a selective inhibitor. Huber does this by performing multidisciplinary methodologies including X-ray crystallography, fluorescence spectroscopy and mutagenesis experiments. Her exceptional results explore the immunoproteasome complex structures and are of outstanding importance for future scientific research especially in the pharmaceutical industry. These results will enable the functional analysis of individual proteasome subunits and support the development of novel drugs for autoimmune diseases such as multiple sclerosis or rheumatoid arthritis. | ||
| 650 | 0 |
_achemistry. _9161768 |
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| 650 | 0 |
_aAnalytical biochemistry. _9304187 |
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| 650 | 0 |
_aBiochemistry. _9299060 |
|
| 650 | 1 | 4 |
_aChemistry. _9161768 |
| 650 | 2 | 4 |
_aAnalytical Chemistry. _9304189 |
| 650 | 2 | 4 |
_aProtein Science. _9410551 |
| 650 | 2 | 4 |
_aMedicinal Chemistry. _9305147 |
| 710 | 2 |
_aSpringerLink (Online service) _9143950 |
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| 773 | 0 | _tSpringer eBooks | |
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_aSpringer Theses, Recognizing Outstanding Ph.D. Research, _9567110 |
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| 856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-3-319-01556-9 |
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| 999 | _c356817 | ||