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| 001 | vtls000484097 | ||
| 003 | RU-ToGU | ||
| 005 | 20210922065800.0 | ||
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| 008 | 140715s2013 gw | s |||| 0|eng d | ||
| 020 |
_a9783319007083 _9978-3-319-00708-3 |
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| 024 | 7 |
_a10.1007/978-3-319-00708-3 _2doi |
|
| 035 | _ato000484097 | ||
| 040 |
_aSpringer _cSpringer _dRU-ToGU |
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| 050 | 4 | _aQD450-882 | |
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_aPNR _2bicssc |
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_aSCI013050 _2bisacsh |
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| 082 | 0 | 4 |
_a541 _223 |
| 100 | 1 |
_aLau, Janet T F. _eauthor. _9414503 |
|
| 245 | 1 | 0 |
_aTowards Dual and Targeted Cancer Therapy with Novel Phthalocyanine-based Photosensitizers _helectronic resource _cby Janet T F Lau. |
| 260 |
_aHeidelberg : _bSpringer International Publishing : _bImprint: Springer, _c2013. |
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| 300 |
_aXXII, 180 p. 212 illus., 39 illus. in color. _bonline resource. |
||
| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bc _2rdamedia |
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| 338 |
_aonline resource _bcr _2rdacarrier |
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| 490 | 1 |
_aSpringer Theses, Recognizing Outstanding Ph.D. Research, _x2190-5053 |
|
| 505 | 0 | _aA Zinc(II) Phthalocyanine Conjugated with an Oxaliplatin Derivative for Dual Chemo- and Photodynamic Therapy -- Zinc(II) Phthalocyanine-Polyamine Conjugates as Efficient Photosensitizers for Photodynamic Therapy -- A Redox-Responsive Silicon(IV) Phthalocyanine for Targeted Photodynamic Therapy -- A Dual pH- and Redox-Responsive Phthalocyanine-Based Photosensitizer for Targeted Photodynamic Therapy. | |
| 520 | _aJanet Lau's thesis describes her studies into the use of phthalocyanine-based photosensitizers in combined chemo- and photodynamic therapy (PDT) and targeted PDT. In order to carry out this study, Lau uses several approaches: conjugation with a chemotherapeutic oxaliplatin derivative, use of a polyamine ligand 2 with a view to targeting the polyamine transporters over-expressed in tumor cells, and employment of a quencher that can inhibit their photodynamic activity but can still be removed under a tumor-associated environment such as low pH and high thiol concentration. This thesis reports dual activatable photosensitizers for the first time. Overall the studies included are original and the effects have been well demonstrated at the cellular level. The work in this thesis is of much current interest and importance, and can pave foundation for further developments. Accordingly, parts of the results have been published in prestigious scientific journals. | ||
| 650 | 0 |
_achemistry. _9161768 |
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| 650 | 0 |
_aOncology. _9303086 |
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| 650 | 0 |
_aChemistry, Physical organic. _9566250 |
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| 650 | 0 |
_aBiochemistry. _9299060 |
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| 650 | 1 | 4 |
_aChemistry. _9161768 |
| 650 | 2 | 4 |
_aPhysical Chemistry. _9566251 |
| 650 | 2 | 4 |
_aMedicinal Chemistry. _9305147 |
| 650 | 2 | 4 |
_aCancer Research. _9566267 |
| 710 | 2 |
_aSpringerLink (Online service) _9143950 |
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| 773 | 0 | _tSpringer eBooks | |
| 830 | 0 |
_aSpringer Theses, Recognizing Outstanding Ph.D. Research, _9567110 |
|
| 856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-3-319-00708-3 |
| 912 | _aZDB-2-CMS | ||
| 999 | _c356759 | ||