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020 _a9781461419914
_9978-1-4614-1991-4
024 7 _a10.1007/978-1-4614-1991-4
_2doi
035 _ato000482333
040 _aSpringer
_cSpringer
_dRU-ToGU
050 4 _aQH505
072 7 _aPHVN
_2bicssc
072 7 _aPHVD
_2bicssc
072 7 _aSCI009000
_2bisacsh
082 0 4 _a571.4
_223
100 1 _aThiriet, Marc.
_eauthor.
_9567122
245 1 0 _aSignaling at the Cell Surface in the Circulatory and Ventilatory Systems
_helectronic resource
_cby Marc Thiriet.
260 _aNew York, NY :
_bSpringer New York,
_c2012.
300 _aXV, 982p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
490 1 _aBiomathematical and Biomechanical Modeling of the Circulatory and Ventilatory Systems ;
_v3
505 0 _aIntroduction -- 1. Signal Transduction -- 2. Ion Carriers -- 3. Main Sets of Ion Channels and Pumps -- 4. Transmembrane Compound Carriers -- 5. Receptors of Cell-Matrix Mass Transfer -- 6. Receptors -- 7. G-Protein-Coupled Receptors -- 8. Receptor Protein Kinases -- 9. Receptor Tyrosine Phosphatases -- 10. Morphogen Receptors -- 11. Receptors of the Immune System -- Concluding Remarks.
520 _aThe volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to nano- and microscopic events in a corrector scheme of regulated mechanisms when the vessel lumen caliber varies markedly. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning. Volume 3 is devoted to the set of mediators of the cell surface, especially ion and molecular carriers and catalytic receptors that, once liganded and activated, initiate signal transduction pathways. Intracellular cascades of chemical reactions trigger the release of substances stored in cellular organelles and/or gene transcription and protein synthesis. Primary mediators are included in models of regulated cellular processes, but multiple secondary signaling components are discarded to allow simple, representative modeling and to manage their inverse problems. Reviews signaling pathways in the regulation of circulatory and respiratory function Describes ion and molecular carriers and receptors Integrates biology, chemistry, and physics for a multidisciplinary understanding of physiological flows
650 0 _aphysics.
_9566227
650 0 _aCardiology.
_9302215
650 0 _aBiological models.
_9332680
650 0 _aHydraulic engineering.
_9294368
650 0 _aBiomedical engineering.
_9302214
650 1 4 _aPhysics.
_9566228
650 2 4 _aBiophysics and Biological Physics.
_9410468
650 2 4 _aBiomedical Engineering.
_9302214
650 2 4 _aMathematical and Computational Biology.
_9411705
650 2 4 _aSystems Biology.
_9332681
650 2 4 _aEngineering Fluid Dynamics.
_9294371
650 2 4 _aCardiology.
_9302215
710 2 _aSpringerLink (Online service)
_9143950
773 0 _tSpringer eBooks
830 0 _aBiomathematical and Biomechanical Modeling of the Circulatory and Ventilatory Systems ;
_9411706
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-1991-4
912 _aZDB-2-PHA
999 _c355050