TY  - SER
AU  - Udut,Vladimir V.
AU  - Naumov,Sergei Alexandrovich
AU  - Evtushenko,Diana Nikolaevna
AU  - Udut,Elena V.
AU  - Naumov,Sergei Sergeevich
AU  - Zyuzkov,Gleb N.
TI  - A case of xenon inhalation therapy for respiratory failure and neuropsychiatric disorders associated with COVID-19
KW  - COVID-19
KW  - ксенон
KW  - сурфактанты
KW  - дыхательная недостаточность
KW  - нервно-психические расстройства
KW  - молекулярное моделирование
KW  - статьи в журналах
N1  - Библиогр.: с. 1523-1525
N2  - Acute respiratory distress syndrome (ARDS) is the main danger to the life of patients with pneumonia caused by SARS-CoV-2. At the same time, respiratory failure (RF) after ARDS can persist for a long time despite intensive therapy. Therefore, it is important to develop new effective approaches for restoring the ventilation function of the lungs after COVID-19. Here, we present a case report of effective application of short-term inhalations of xenon-oxygen (Xe/O2) gas mixture for treatment of RF and neuropsychiatric disorders (NPD) associated with COVID-19. The patient inhaled a gas mixture of 70 % Xe and 30 % O2. We used multispiral computed tomog-raphy, evaluated psychometry, studied hematological and biochemical blood parameters, and applied some other methods of clinical studies to assess the therapeutic effectiveness of Xe inhalation. Also, we studied the mecha-nism of action of xenon with computer modeling. The clinical case showed the high efficacy of Xe/O2 mixture for treating severe RF and NPD after SARS-CoV-2 infection. Xenon inhalations dramatically increased oxygen saturation and the degree of pneumatization of the lungs. We found out that in coronavirus pneumonia, saturated phospholipids of surfactant are transferred to the solid-ordered phase, which disrupts the surface tension of the alveoli and alveolar gas exchange. Using molecular modeling methods, we demonstrated that the xenon atom in-creases the distance between the acyl chains of phospholipids due to the van der Waals dispersion interaction. These changes allow for the phase transition of phospholipids from the solid-ordered phase to the liquid phase and restore the functional activity of the surfactant. The findings suggest the feasibility of conducting studies on the effectiveness of Xe/O2 inhalations for treating ARDS in SARS-CoV-2 infection
UR  - http://vital.lib.tsu.ru/vital/access/manager/Repository/koha:000893958
ER  -