TY  - SER
AU  - Synowiec,Sylvia
AU  - Lu,Lei
AU  - Yu,Yueyue
AU  - Bretherick,Talitha
AU  - Takada,Silvia
AU  - Yarnykh,Vasily L.
AU  - Caplan,Jack
AU  - Caplan,Michael
AU  - Claud,Erika C.
AU  - Drobyshevsky,Alexander
AU  - Lu,Jing
TI  - Microbiota influence the development of the brain and behaviors in C57BL/6J mice
KW  - магнитно-резонансная томография
KW  - мыши
KW  - микробиота
KW  - созревание головного мозга
KW  - поведенческие тесты
KW  - комменсальные бактерии
KW  - статьи в журналах
N1  - Библиогр.: 108 назв
N2  - We investigated the contributions of commensal bacteria to brain structural maturation by magnetic resonance imaging and behavioral tests in four and 12 weeks old C57BL/6J specific pathogen free (SPF) and germ free (GF) mice. SPF mice had increased volumes and fractional anisotropy in major gray and white matter areas and higher levels of myelination in total brain, major white and grey matter structures at either four or 12 weeks of age, demonstrating better brain maturation and organization. In open field test, SPF mice had better mobility and were less anxious than GF at four weeks. In Morris water maze, SPF mice demonstrated better spatial and learning memory than GF mice at 12 weeks. In fear conditioning, SPF mice had better contextual memory than GF mice at 12 weeks. In three chamber social test, SPF mice demonstrated better social novelty than GF mice at 12 weeks. Our data demonstrate numerous significant differences in morphological brain organization and behaviors between SPF and GF mice. This suggests that commensal bacteria are necessary for normal morphological development and maturation in the grey and white matter of the brain regions with implications for behavioral outcomes such as locomotion and cognitive functions
UR  - http://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000673874
ER  -