TY  - GEN
AU  - Мурашкина,Анастасия Александровна
AU  - Савченко,Рената Ренатовна
TI  - Влияние нокаута генов ADAMTS1, RBFOX2 и THBS1 на транскрипционную регуляцию и клональную выживаемость клеток в модельной системе in vitro
KW  - гены
KW  - радиочувствительность
KW  - онкологические заболевания
KW  - двунитевые разрывы ДНК
KW  - нокаут генов
KW  - статьи в сборниках
N1  - Библиогр.: 3 назв
N2  - In this study, we evaluated the expression level and clonogenic survival of cell lines with a mutation of the ADAMTSl, RBFOX2, and THBSl genes generated by CRISPR/Cas9 technology. The gene expression profile was analyzed by expression microarray. It was found that knockout of all analyzed genes leads to a decrease in their own expression. In addition, the knockout of these genes leads to significant changes in the expression of other genes in the cell lines. Clonogenic survival of the lines was decreased in the cell lines with knockout of ADAMTSl and RBFOX2 genes after exposure to 2 Gy of y-rays
UR  - http://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000635465
ER  -