TY  - BOOK
AU  - Ghadimi,B.Michael
AU  - Ried,Thomas
ED  - SpringerLink (Online service)
TI  - Chromosomal Instability in Cancer Cells
T2  - Recent Results in Cancer Research,
SN  - 9783319202914
AV  - RC254-282 
U1  - 616.994 23
PY  - 2015///
CY  - Cham
PB  - Springer International Publishing, Imprint: Springer
KW  - medicine
KW  - Cancer Research
KW  - Human genetics
KW  - Oncology
KW  - Medicine & Public Health
KW  - Human Genetics
N1  - DNA Repair and Chromosomal Translocations -- CINcere modelling: What have mouse models for chromosome instability taught us? -- Telomere Dysfunction, Chromosomal Instability and Cancer -- Genetic Instability and Disease Prognostication -- Causes of Chromosomal Instability -- Patterns of Chromosomal Aberrations in Solid Tumors -- Yeast as Models of Mitotic Fidelity -- The diverse effects of complex chromosome rearrangements and chromothripsis in cancer development -- Consequences of aneuploidy in cancer: transcriptome and beyond
N2  - This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification
UR  - http://dx.doi.org/10.1007/978-3-319-20291-4
ER  -