TY  - BOOK
AU  - Inuzuka,Hiroyuki
AU  - Wei,Wenyi
ED  - SpringerLink (Online service)
TI  - SCF and APC E3 Ubiquitin Ligases in Tumorigenesis
T2  - SpringerBriefs in Cancer Research
SN  - 9783319050263
AV  - RC261-271 
U1  - 614.5999 23
PY  - 2014///
CY  - Cham
PB  - Springer International Publishing, Imprint: Springer
KW  - medicine
KW  - Oncology
KW  - Biochemistry
KW  - Cell cycle
KW  - Biomedicine
KW  - Cancer Research
KW  - Cell Cycle Analysis
KW  - Protein Structure
N1  - 1. Introduction -- 2. The Fbxw subclass of SCF E3 ubiquitin Ligases -- 3. The FbxL subclass of SCF E3 ubiquitin Ligases -- 4. The Fbxo subclass of SCF E3 ubiquitin Ligases -- 5. APC/Cdc20 and APC/Cdh1 E3 ubiquitin Ligases -- 6. Conclusions and Future Perspectives
N2  - This SpringerBrief explores the physiological roles of Skp1-Cullin1-F-box Complex (SCF) and Anaphase Promoting Complex (APC) in normal cells and in tumor formation. These two related, multi-subunit E3 ubiquitin ligase enzymes, APC and SCF are thought to be the major driving forces governing proper cell cycle progression. Defective cell cycle regulation leads to genomic instability and ultimately, cancer development. Selective degradation of key cell cycle regulators by the ubiquitin-proteasome system has been proven to be a major regulatory mechanism for ensuring ordered and coordinated cell cycle progression. The SCF and APC E3 ligases have been characterized to play pivotal roles in regulating the cell cycle progression by timely degrading various critical cell cycle regulators. This Brief reviews recent studies that have shown that deregulation of signaling pathways in which the two ubiquitin ligases are involved causes aberrant cell cycle regulation, in turn leading to tumorigenesis. The text also discusses how SCF and APC may present promising therapeutic targets to treat various cancers
UR  - http://dx.doi.org/10.1007/978-3-319-05026-3
ER  -