TY  - BOOK
AU  - Huber,Eva Maria
ED  - SpringerLink (Online service)
TI  - Structural and Functional Characterization of the Immunoproteasome
T2  - Springer Theses, Recognizing Outstanding Ph.D. Research,
SN  - 9783319015569
AV  - QD71-142 
U1  - 543 23
PY  - 2013///
CY  - Cham
PB  - Springer International Publishing, Imprint: Springer
KW  - chemistry
KW  - Analytical biochemistry
KW  - Biochemistry
KW  - Chemistry
KW  - Analytical Chemistry
KW  - Protein Science
KW  - Medicinal Chemistry
N1  - Introduction -- Objective -- Materials and Methods -- Results -- Discussion -- Appendix
N2  - In this acclaimed thesis, Eva Maria Huber reveals ground-breaking results by elucidating the crystal structure of the murine immunoproteasome in complex with a selective inhibitor. Huber does this by performing multidisciplinary methodologies including X-ray crystallography, fluorescence spectroscopy and mutagenesis experiments. Her exceptional results explore the immunoproteasome complex structures and are of outstanding importance for future scientific research especially in the pharmaceutical industry. These results will enable the functional analysis of individual proteasome subunits and support the development of novel drugs for autoimmune diseases such as multiple sclerosis or rheumatoid arthritis
UR  - http://dx.doi.org/10.1007/978-3-319-01556-9
ER  -