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Модификация поверхности титановых имплантатов с помощью микродугового оксидирования в присутствии растворов полимеров. Оценка иммунного ответа А. А. Ракина

By: Ракина, Аполлинария АлександровнаMaterial type: ArticleArticleOther title: Modification of titanium implants surface by micro arc oxidation in presence of polymeric solutions. The study of immune response [Parallel title]Subject(s): титановые имплантаты | микродуговое оксидирование | биосовместимость материалов | кальций-фосфатные покрытияGenre/Form: статьи в сборниках Online resources: Click here to access online In: Перспективы развития фундаментальных наук. Т. 4 : сборник научных трудов XV Международной конференции студентов, аспирантов и молодых ученых, 24-27 апреля 2018 г Том 4 : Биология и фундаментальная медицина. С. 125-127Abstract: In the present study, we performed the in vitro evaluation of titanium samples with four types of coatings obtained by microarc oxidation (MAO): pure calcium phosphate (CaP), CaP- chitosan, CaP- hyaluronic acid, CaP - polyvinylpyrrolidone coatings. AlamarBlue test and TNFa secretion analysis (ELISA) were performed to investigate the immune response. It was shown that formation of MAO hybrid calcium- phosphate coatings increases the biocompatibility of samples. Adding of polyvinylpyrrolidone and hyaluronic acid to the electrolyte solution presumably makes it possible to obtain hybrid coatings with anti-inflammatory properties.
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In the present study, we performed the in vitro evaluation of titanium samples with four types of coatings obtained by microarc oxidation (MAO): pure calcium phosphate (CaP), CaP- chitosan, CaP- hyaluronic acid, CaP - polyvinylpyrrolidone coatings. AlamarBlue test and TNFa secretion analysis (ELISA) were performed to investigate the immune response. It was shown that formation of MAO hybrid calcium- phosphate coatings increases the biocompatibility of samples. Adding of polyvinylpyrrolidone and hyaluronic acid to the electrolyte solution presumably makes it possible to obtain hybrid coatings with anti-inflammatory properties.

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