Pharmacotherapy of Pulmonary Hypertension electronic resource edited by Marc Humbert, Oleg V. Evgenov, Johannes-Peter Stasch.
Material type: TextSeries: Handbook of Experimental PharmacologyPublication details: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2013Description: IX, 576 p. 66 illus., 56 illus. in color. online resourceContent type: text Media type: computer Carrier type: online resourceISBN: 9783642386640Subject(s): medicine | Medical laboratories | Toxicology | Pharmaceutical technology | Internal medicine | Pneumology | Biomedicine | Pharmacology/Toxicology | Pharmaceutical Sciences/Technology | Internal Medicine | Pneumology/Respiratory System | Laboratory Medicine | Molecular MedicineDDC classification: 615 LOC classification: RM1-950Online resources: Click here to access onlinePreface.- Part I. Pulmonary hypertension: conceptual bases of the disease. Pulmonary hypertension: definition, classification, and epidemiology. Pulmonary hypertension: pathophysiology and signalling pathways. Pulmonary hypertension: pathology. Pulmonary hypertension: biomarkers. Pulmonary hypertension: animal models -- Part II. Pulmonary hypertension: established therapies. General supportive care. Calcium channel blockers. Prostacyclins. Endothelin receptor antagonists. Phosphodiesterase 5 inhibitors -- Part III. Pulmonary hypertension: novel pathways and emerging therapies Soluble guanylate cyclase stimulators. Therapeutics targeting dysregulated redox equilibrium and endothelial dysfunction (NOXs, sGC activators, GSNOR). Rho-kinase inhibitors. Serotonin transporters and serotonin receptors. PDGF inhibitors. Novel anti-proliferative strategies beyond imatinib. Immunosuppressive agents. Vasoactive peptides. Inhibitors of cGMP/cAMP metabolism (MRP4, MRP5, PDE1). Old targets re-visited. Stem cells and cell based therapy -- Part IV. Conclusions and Outlook. Pulmonary hypertension: evidence-based management in the modern era and future directions.
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