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Effect of chronic alcohol abuse on the benzodiazepine receptor system in various areas of the human brain (Record no. 406110)
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| 000 -Маркер записи | |
|---|---|
| Контрольное поле постоянной длины | 03694nab a2200349 c 4500 |
| 001 - Контрольный номер | |
| Контрольное поле | vtls000550142 |
| 005 - Дата корректировки | |
| Контрольное поле | 20220707152808.0 |
| 007 - Кодируемые данные (физ. описан.) | |
| Контрольное поле постоянной длины | cr | |
| 008 - Кодируемые данные | |
| Контрольное поле постоянной длины | 181202|2016 xxu s a eng dd |
| 024 7# - Прочие стандартные номера | |
| Стандартный номер | 10.4172/2378-5756.1000365 |
| Источник номера | doi |
| 035 ## - Системный контрольный номер | |
| Системный контрольный номер | to000550142 |
| 040 ## - Источник каталогиз. | |
| Служба первич. каталог. | RU-ToGU |
| Код языка каталог. | rus |
| Служба, преобразующая запись | RU-ToGU |
| 245 10 - Заглавие | |
| Заглавие | Effect of chronic alcohol abuse on the benzodiazepine receptor system in various areas of the human brain |
| Ответственность | T. V. Shushpanova, N. A. Bokhan, V. F. Lebedeva [et.al.] |
| 504 ## - Библиография | |
| Библиография | Библиогр.: 31 назв. |
| 520 3# - Аннотация | |
| Аннотация | Objective: Alcohol abuse induces neuroadaptive changes in the functioning of neurotransmitter systems in the brain. Decrease of GABAergic neurotransmission found in alcoholics and persons with a high risk of alcohol dependence. Benzodiazepine receptor (BzDR) is allosterical modulatory site on GABA type A receptor complex (GABAAR), that modulate GABAergic function and may be important in mechanisms regulating the excitability of the brain processes involved in the alcohol addiction. The purpose of this study was to investigate the effects of chronic alcohol abuse on the BzDR in various areas of the human brain.<br/>Materials and Methods: Investigation of BzDR properties were studied in synaptosomal and mitochondrial membrane fractions from different brain areas of alcohol abused patients and non-alcoholic persons by radioreceptor assay with using selective ligands: [3H] flunitrazepam and [3H] PK-11195. Brain samples obtained at autopsy urgent. In total 126 samples of human brain areas were obtained to study radioreceptor binding, including a study group and control group.<br/> Results: Comparative study of kinetic parameters (Kd, Bmax) of [3H] flunitrazepam and [3H] PK-11195 binding with membrane fractions in studding brain samples was showed that affinity of BzDR was decreased and capacity increased in different areas of human brain under influence of alcohol abuse. More alters of synaptic BzDR “central” type (CBR) appeared in prefrontal cortex, mitochondrial BzDR “peripheral” type (PBR) – in n.caudatus and cerebella cortex. These results showed that alcohol addiction induce more expressive alterations in PBR than CBR in the brain structures that agree with maintaining function of glial cells in CNS under influence of different toxic factors.<br/> Conclusion: Chronic exposure to ethanol results in harmful effects on the human brain: causing nonuniform adaptive changes of BzDR in various areas of the brain, which can modulate GABAAR and reduce neuromediation GABA in various areas of the brain which can cause alcohol addiction.<br/> Graphical Abstract: Alcohol abuse induces neuroadaptive alters of benzodiazepine receptor system in various areas of the brain in patients with alcoholism that can modulate GABAAR and mediation of GABA in the brain, which can cause alcohol addiction. |
| 653 ## - Ключевые слова | |
| Ключевые слова | алкоголизм |
| 653 ## - Ключевые слова | |
| Ключевые слова | головной мозг |
| 653 ## - Ключевые слова | |
| Ключевые слова | нейроадаптация |
| 653 ## - Ключевые слова | |
| Ключевые слова | бензодиазепины |
| 655 #4 - Термин индексирования — жанр/форма | |
| Жанр/форма | статьи в журналах |
| 9 (RLIN) | 681159 |
| 700 1# - Другие авторы | |
| Другие авторы | Shushpanova, Tamara V. |
| 9 (RLIN) | 457188 |
| 700 1# - Другие авторы | |
| Другие авторы | Lebedeva, Valentina F. |
| 9 (RLIN) | 457189 |
| 700 1# - Другие авторы | |
| Другие авторы | Solonskii, A. V. |
| 9 (RLIN) | 457190 |
| 700 1# - Другие авторы | |
| Другие авторы | Udut, Vladimir V. |
| 9 (RLIN) | 404503 |
| 700 1# - Другие авторы | |
| Другие авторы | Bokhan, Nikolay A. |
| 9 (RLIN) | 285482 |
| 773 0# - Источник информации | |
| Название источника | Journal of psychiatry |
| Место и дата издания | 2016 |
| Прочая информация | Vol. 19, № 3. P. 1000365 (1-6) |
| ISSN | 0033-2747 |
| 852 4# - Местонахождение единицы хранения | |
| Код организации-хранителя | RU-ToGU |
| 856 7# - Электронный адрес документа | |
| URL | <a href="http://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000550142">http://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000550142</a> |
| 908 ## - Параметр входа данных | |
| Параметр входа данных | статья |
| 999 ## - Системные контрольные номера (Koha) | |
| biblionumber (Koha) | 406110 |
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