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Regulatory Toxicology (Record no. 401932)
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| 000 -Маркер записи | |
|---|---|
| Контрольное поле постоянной длины | 06580nam a22004935i 4500 |
| 001 - Контрольный номер | |
| Контрольное поле | vtls000544429 |
| 005 - Дата корректировки | |
| Контрольное поле | 20210922082930.0 |
| 007 - Кодируемые данные (физ. описан.) | |
| Контрольное поле постоянной длины | cr nn 008mamaa |
| 008 - Кодируемые данные | |
| Контрольное поле постоянной длины | 160915s2014 gw | s |||| 0|eng d |
| 020 ## - Индекс ISBN | |
| ISBN | 9783642353741 |
| -- | 978-3-642-35374-1 |
| 024 7# - Прочие стандартные номера | |
| Стандартный номер | 10.1007/978-3-642-35374-1 |
| Источник номера | doi |
| 035 ## - Системный контрольный номер | |
| Системный контрольный номер | to000544429 |
| 040 ## - Источник каталогиз. | |
| Служба первич. каталог. | Springer |
| Служба, преобразующая запись | Springer |
| Организация, изменившая запись | RU-ToGU |
| 050 #4 - Расстановочный код библ. Конгресса | |
| Классификационный индекс | RM1-950 |
| 072 #7 - Код предметной/темат. категории | |
| Код предметной/темат. категории | MMG |
| Источник кода | bicssc |
| 072 #7 - Код предметной/темат. категории | |
| Код предметной/темат. категории | MED071000 |
| Источник кода | bisacsh |
| 082 04 - Индекс Дьюи | |
| Индекс Дьюи | 615 |
| Номер издания | 23 |
| 245 10 - Заглавие | |
| Заглавие | Regulatory Toxicology |
| Физический носитель | electronic resource |
| Ответственность | edited by Franz-Xaver Reichl, Michael Schwenk. |
| 260 ## - Выходные данные | |
| Место издания | Berlin, Heidelberg : |
| Издательство | Springer Berlin Heidelberg : |
| -- | Imprint: Springer, |
| Дата издания | 2014. |
| 300 ## - Физическое описание | |
| Объем | XXIV, 946 p. 144 illus., 70 illus. in color. eReference. |
| Иллюстрации/тип воспроизводства | online resource. |
| 336 ## - Тип содержимого | |
| Тип содержимого | text |
| Content type code | txt |
| Source | rdacontent |
| 337 ## - Средство доступа | |
| Средство доступа | computer |
| Media type code | c |
| Source | rdamedia |
| 338 ## - Тип носителя | |
| Тип носителя | online resource |
| Carrier type code | cr |
| Source | rdacarrier |
| 505 0# - Примечание о содержании | |
| Содержание | Foreword -- Introduction -- Operation mode of regulatory toxicology -- Aims and institutions -- Aims and mission -- Application areas -- National and international collaboration -- Procedures and standards -- The regulatory process -- Quality assurance in regulatory toxcicology -- Toxicological risk assessment -- Methodological repertoire -- Toxicological tests -- Characterization of physicochemical parameters -- Examination of acute and chronic toxicity -- Examination of organ-toxicity and of laboratory parameters -- Specific tests for neurotox , immunotox, allergy, irritation, reprotox and carcinogenicity -- Toxicity testing in vitro -- New and future toxicological assays -- Computer-based prediction models -- Metabolism tests -- Toxicokinetic tests -- Toxicodynamic tests -- Omics -- International regulation for toxicological test procedures -- Data acquisition in humans -- Epidemiological methods -- Studies in volunteers -- Chemical analysis in toxicology (New) -- Toxicostatistics and models -- Statistical evaluation methods -- Dose-response analysis, identification of threshold levels -- Extrapolation-procedures for carcinogenic and non-carcinogenic compounds -- Probabilistic methods -- Toxicodynamic models -- Toxicokinetic models -- Estimation of exposure -- Exposure analysis for indoor contaminants -- Exposure scenarios -- Use of toxiological data -- Quality criteria for primary literature -- Data-mining -- Paradigms use in risk evaluation -- Toxicological paradigms -- Do carcinogens have a threshold dose? pro and contra -- Single compounds vs combination effects -- Biomolecules vs smaller chemicals -- Sensitive humans vs average persons -- Assessment paradigmas -- Extrapolation factors and safety factors -- Background exposure vs additional exposure in human biomonitoring -- Adverse effects vs non-adverse effects -- ADI vs MOS principle -- Precaution principle vs hazard control -- Hygienic vs toxicological approaches -- Protected property and protection level -- Risk characterization and risk evaluation -- The risk concept -- Current role of the term "risk" -- Risk cycles -- Risk minimization in drug development -- Data required for risk evaluation -- Importance of physical-chemical properties -- Importance of intrinsic toxic properties -- Importance of metabolism and of mechanism of action -- Importance of the extrapolation to lower doses in risk assessment -- Importance of exposure level for risk assessment -- Risk characterization -- Risk assessment -- Elements of risk assessment -- Risk comparison -- Risk-benefit considerations -- Risk assessment in different jurisdictions -- Reach as a regulatory instrument (New) -- Risk management and risk communication -- Risk management -- Purpose of risk management -- Assessment of limit values -- Deduction of limit values in different areas -- Registration and approval -- Classification and labelling -- Monitoring unwanted exposures and effects -- Restrictions and prohibitions -- Observance of susceptible population groups -- The toxicological expert report -- Risk management in toxicological emergencies -- Risk communication and participation of affected people -- Institutionalized participation -- The technique of risk communication -- Dealing with diseases that have been attributed to chemical exposures -- Addendum: tables and lists -- Checklist: Toxicological risk assessment in practice -- Glossary and risk terms -- Limit values, guideline values, tables -- Proposed additional chapters on Ethics in toxicology and expansion of the chapter dealing with Immunotoxicology. |
| 520 ## - Аннотация | |
| Аннотация | This book will be written by experts for professionals, scientists and all those involved in toxicological data generation and decision-making. It is the updated and expanded version of a monograph published in German in 2004. Chemical safety is regulated on various levels including production, storage, transport, handling, disposal or labelling. This book deals comprehensively with the safety-ensuring methods and concepts employed by regulatory agencies, industry and academics. Toxicologists use experimental and scientific approaches for data collection, e.g. about chemical hazards, physicochemical features or toxicokinetics. The respective experimental methods are described in the book. Toxicologists also deal with much insecurity in the exposure and effect scenarios during risk assessment. To overcome these, they have different extrapolation methods and estimation procedures at their disposal. The book describes these methods in an accessible manner. Differing concepts from one regulation area to another are also covered. Reasons and consequences become evident when reading the book. Altogether, the book Regulatory Toxicology will serve as an excellent reference. |
| 650 #0 - Тематические рубрики | |
| Основная рубрика | medicine. |
| 9 (RLIN) | 566220 |
| 650 #0 - Тематические рубрики | |
| Основная рубрика | Toxicology. |
| 9 (RLIN) | 302218 |
| 650 #0 - Тематические рубрики | |
| Основная рубрика | Chemicals |
| Основная подрубрика | Safety measures. |
| 9 (RLIN) | 311855 |
| 650 #0 - Тематические рубрики | |
| Основная рубрика | Medicine, Industrial. |
| 9 (RLIN) | 308313 |
| 650 14 - Тематические рубрики | |
| Основная рубрика | Biomedicine. |
| 9 (RLIN) | 566246 |
| 650 24 - Тематические рубрики | |
| Основная рубрика | Pharmacology/Toxicology. |
| 9 (RLIN) | 302222 |
| 650 24 - Тематические рубрики | |
| Основная рубрика | Occupational Medicine/Industrial Medicine. |
| 9 (RLIN) | 308314 |
| 650 24 - Тематические рубрики | |
| Основная рубрика | Biomedicine general. |
| 9 (RLIN) | 566281 |
| 650 24 - Тематические рубрики | |
| Основная рубрика | Safety in Chemistry, Dangerous Goods. |
| 9 (RLIN) | 311856 |
| 700 1# - Другие авторы | |
| Другие авторы | Reichl, Franz-Xaver. |
| Роль лиц | editor. |
| 9 (RLIN) | 451581 |
| 700 1# - Другие авторы | |
| Другие авторы | Schwenk, Michael. |
| Роль лиц | editor. |
| 9 (RLIN) | 451582 |
| 710 2# - Другие организации | |
| Организация/юрисдикция | SpringerLink (Online service) |
| 9 (RLIN) | 143950 |
| 773 0# - Источник информации | |
| Название источника | Springer eBooks |
| 856 40 - Электронный адрес документа | |
| URL | <a href="http://dx.doi.org/10.1007/978-3-642-35374-1">http://dx.doi.org/10.1007/978-3-642-35374-1</a> |
| 912 ## - Coursera for Campus: онлайн курсы для ТГУ | |
| Coursera for Campus: онлайн курсы для ТГУ | ZDB-2-SBL |
| 999 ## - Системные контрольные номера (Koha) | |
| biblionumber (Koha) | 401932 |
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