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Macrophages: Biology and Role in the Pathology of Diseases (Record no. 399527)
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| 000 -Маркер записи | |
|---|---|
| Контрольное поле постоянной длины | 05149nam a22004815i 4500 |
| 001 - Контрольный номер | |
| Контрольное поле | vtls000541676 |
| 005 - Дата корректировки | |
| Контрольное поле | 20210922082152.0 |
| 007 - Кодируемые данные (физ. описан.) | |
| Контрольное поле постоянной длины | cr nn 008mamaa |
| 008 - Кодируемые данные | |
| Контрольное поле постоянной длины | 160915s2014 xxu| s |||| 0|eng d |
| 020 ## - Индекс ISBN | |
| ISBN | 9781493913114 |
| -- | 978-1-4939-1311-4 |
| 024 7# - Прочие стандартные номера | |
| Стандартный номер | 10.1007/978-1-4939-1311-4 |
| Источник номера | doi |
| 035 ## - Системный контрольный номер | |
| Системный контрольный номер | to000541676 |
| 040 ## - Источник каталогиз. | |
| Служба первич. каталог. | Springer |
| Служба, преобразующая запись | Springer |
| Организация, изменившая запись | RU-ToGU |
| 050 #4 - Расстановочный код библ. Конгресса | |
| Классификационный индекс | QR180-189.5 |
| 072 #7 - Код предметной/темат. категории | |
| Код предметной/темат. категории | MJCM |
| Источник кода | bicssc |
| 072 #7 - Код предметной/темат. категории | |
| Код предметной/темат. категории | MED044000 |
| Источник кода | bisacsh |
| 082 04 - Индекс Дьюи | |
| Индекс Дьюи | 616.079 |
| Номер издания | 23 |
| 245 10 - Заглавие | |
| Заглавие | Macrophages: Biology and Role in the Pathology of Diseases |
| Физический носитель | electronic resource |
| Ответственность | edited by Subhra K. Biswas, Alberto Mantovani. |
| 260 ## - Выходные данные | |
| Место издания | New York, NY : |
| Издательство | Springer New York : |
| -- | Imprint: Springer, |
| Дата издания | 2014. |
| 300 ## - Физическое описание | |
| Объем | IX, 615 p. 77 illus. |
| Иллюстрации/тип воспроизводства | online resource. |
| 336 ## - Тип содержимого | |
| Тип содержимого | text |
| Content type code | txt |
| Source | rdacontent |
| 337 ## - Средство доступа | |
| Средство доступа | computer |
| Media type code | c |
| Source | rdamedia |
| 338 ## - Тип носителя | |
| Тип носителя | online resource |
| Carrier type code | cr |
| Source | rdacarrier |
| 505 0# - Примечание о содержании | |
| Содержание | Part I Macrophage: Origin, Activation And Polarization -- Blood monocytes and their subsets in health and disease -- Polarized activation of macrophages -- Alternative activation of macrophages: concepts and prospects -- Regulatory macrophages and the maintenance of homeostasis -- Part II Macrophages And Their Diverse Functions -- Phagocytosis -- The antimicrobial functions of macrophages -- Vascular modulatory functions of macrophages -- Part III Macrophages In Different Tissues -- Airway macrophages: sentinels of health -- Microglial ontogeny and functions in shaping brain circuits -- Kupffer cells in health and disease -- Intestinal Macrophages: Specialized antigen-presenting cells at the front line -- Part IV Macrophages In Pathology -- The wound macrophage - Macrophages and the entrance of resolution phase lipid mediators -- Macrophages in sepsis progression -- Adaptive characteristics of innate immune responses in macrophages -- African trypanosomiasis as paradigm for involvement of the mononuclear phagocyte system in pathogenicity during parasite infection -- Macrophages in obesity and insulin resistance -- Macrophages govern the progression and termination of inflammation in atherosclerosis and metabolic diseases -- Myelomonocytic subsets in tumor microenvironment -- Tumor associated macrophages -- Part V Transcriptional And Epigenetic Mechanisms -- Role of NF-kB activation in macrophages -- Interferon Regulatory Factors: Role in transcriptional regulation of macrophage plasticity and activation -- Kruppel-like factors in Monocyte-Macrophage Biology -- Regulation of macrophage polarization by the STAT-SOCS signaling axis -- Functions of the large Maf transcription factors and macrophages -- The Control of Gene Expression in Macrophages -- Role of microRNA in macrophage activation and polarization -- Part VI Systems Biology Of Macrophages -- The macrophage transcriptome -- Omics approaches in macrophage biology -- Appendix. |
| 520 ## - Аннотация | |
| Аннотация | Macrophages are a key component of the innate immune system and play an integral role in host defense and homeostasis. On one hand, these cells contribute to host defence by triggering inflammation, displaying microbicidal/tumoricidal properties, regulating the activation of adaptive immunity and promoting resolution of inflammation. On the other hand, they contribute to essential trophic functions such as neural patterning, bone morphogenesis and ductal branching in mammary glands. Thus, macrophages are extremely versatile cells that can respond efficiently to tissue microenvironmental cues by polarizing to distinct phenotypes, depending on the functions they need to perform. Indeed, functional diversity and plasticity are hallmarks of these cells. Macrophages may also play a detrimental role. An overwhelming body of literature has indicated their crucial role in pathogenesis. The list includes sepsis, cancer, metabolic syndrome, immunodeficiency, auto-immune disease- virtually impacting every major pathology that we know. These observations have suggested macrophages and their related molecules as potential targets in therapeutic applications. Available evidence proclaims macrophages as a key player in homeostasis, host defense and disease. Crucial developments in the past few years call for a re-evaluation and update of our understanding of macrophages. The present book is an endeavour that attempts to provide state-of-the art knowledge of these cells in health and disease. |
| 650 #0 - Тематические рубрики | |
| Основная рубрика | medicine. |
| 9 (RLIN) | 566220 |
| 650 #0 - Тематические рубрики | |
| Основная рубрика | Immunology. |
| 9 (RLIN) | 303380 |
| 650 #0 - Тематические рубрики | |
| Основная рубрика | Monoclonal antibodies. |
| 9 (RLIN) | 414055 |
| 650 #0 - Тематические рубрики | |
| Основная рубрика | microbiology. |
| 9 (RLIN) | 566253 |
| 650 14 - Тематические рубрики | |
| Основная рубрика | Biomedicine. |
| 9 (RLIN) | 566246 |
| 650 24 - Тематические рубрики | |
| Основная рубрика | Immunology. |
| 9 (RLIN) | 303380 |
| 650 24 - Тематические рубрики | |
| Основная рубрика | Antibodies. |
| 9 (RLIN) | 414056 |
| 650 24 - Тематические рубрики | |
| Основная рубрика | Medical Microbiology. |
| 9 (RLIN) | 303382 |
| 700 1# - Другие авторы | |
| Другие авторы | Biswas, Subhra K. |
| Роль лиц | editor. |
| 9 (RLIN) | 447289 |
| 700 1# - Другие авторы | |
| Другие авторы | Mantovani, Alberto. |
| Роль лиц | editor. |
| 9 (RLIN) | 309163 |
| 710 2# - Другие организации | |
| Организация/юрисдикция | SpringerLink (Online service) |
| 9 (RLIN) | 143950 |
| 773 0# - Источник информации | |
| Название источника | Springer eBooks |
| 856 40 - Электронный адрес документа | |
| URL | <a href="http://dx.doi.org/10.1007/978-1-4939-1311-4">http://dx.doi.org/10.1007/978-1-4939-1311-4</a> |
| 912 ## - Coursera for Campus: онлайн курсы для ТГУ | |
| Coursera for Campus: онлайн курсы для ТГУ | ZDB-2-SBL |
| 999 ## - Системные контрольные номера (Koha) | |
| biblionumber (Koha) | 399527 |
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